Effect of off-plane bifurcation angles of primary bronchi on expiratory flows in the human trachea
DC Field | Value | Language |
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dc.contributor.author | Suh, Youngjoon | - |
dc.contributor.author | Park, Joong Yull | - |
dc.date.available | 2019-01-22T13:29:32Z | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 0010-4825 | - |
dc.identifier.issn | 1879-0534 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/985 | - |
dc.description.abstract | Background: The human airway is exposed to the development of diverse flow patterns based on differences in its morphological/geometrical parameters across individuals. Although effects of the asymmetry between the right and left main bronchi on airway flows have been investigated in the past, there exists a paucity in terms of studies that focus on the role of stronger physiological asymmetric features, such as off-plane bifurcation angles of primary bronchi, in expiratory flows. Method: Computational fluid dynamic techniques have been used to demonstrate presence of Dean-type secondary flows and vortices in the bifurcation region. Formation of a distinctive pattern was observed corresponding to an increase in the off-plane branching angle. An experiment involving 3D printed airways and smoke was also performed to visualize flow patterns and verify simulation results. Results: Good agreement was observed between computational and experimental results. Furthermore, it was revealed that the predicted wall shear stress distribution demonstrated significant changes (with a maximum shear stress increase of 30.7%) compared to conventional airway models that adopt symmetric bifurcation angles. The overall flow demonstrated a swerving motion, which was characterized by tracking the vortex cores (maximum accumulated radial movement of 72.6 degrees) when they ascended towards the trachea inlet in off-plane airway models. Conclusions: It was confirmed that off-plane bifurcations in human trachea significantly alter the flow characteristics in expiratory flows. It is expected that the results of this study will provide useful information regarding increasingly advanced patient-specific treatments for respiratory diseases in the trachea. | - |
dc.format.extent | 12 | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Effect of off-plane bifurcation angles of primary bronchi on expiratory flows in the human trachea | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.compbiomed.2018.01.014 | - |
dc.identifier.bibliographicCitation | COMPUTERS IN BIOLOGY AND MEDICINE, v.95, pp 63 - 74 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000430768000007 | - |
dc.identifier.scopusid | 2-s2.0-85042093870 | - |
dc.citation.endPage | 74 | - |
dc.citation.startPage | 63 | - |
dc.citation.title | COMPUTERS IN BIOLOGY AND MEDICINE | - |
dc.citation.volume | 95 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Off-plane bifurcation | - |
dc.subject.keywordAuthor | Patient-specific expiratory flow pattern | - |
dc.subject.keywordAuthor | Rotating airflow in trachea | - |
dc.subject.keywordAuthor | Three-dimensional human airway geometry | - |
dc.subject.keywordPlus | COMPUTATIONAL FLUID-DYNAMICS | - |
dc.subject.keywordPlus | HUMAN LUNG AIRWAY | - |
dc.subject.keywordPlus | PARTICLE DEPOSITION | - |
dc.subject.keywordPlus | AEROSOL DEPOSITION | - |
dc.subject.keywordPlus | SHEAR-STRESS | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | SIMULATION | - |
dc.subject.keywordPlus | GEOMETRY | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalResearchArea | Computer Science | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Mathematical & Computational Biology | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.relation.journalWebOfScienceCategory | Computer Science, Interdisciplinary Applications | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Mathematical & Computational Biology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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