Antimicrobial peptides of the genus Bacillus: a new era for antibiotics
DC Field | Value | Language |
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dc.contributor.author | Sumi, Chandra Datta | - |
dc.contributor.author | Yang, Byung Wook | - |
dc.contributor.author | Yeo, In-Cheol | - |
dc.contributor.author | Hahm, Young Tae | - |
dc.date.available | 2019-03-08T17:59:08Z | - |
dc.date.issued | 2015-02 | - |
dc.identifier.issn | 0008-4166 | - |
dc.identifier.issn | 1480-3275 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9922 | - |
dc.description.abstract | The rapid onset of resistance reduces the efficacy of most conventional antimicrobial drugs and is a general cause of concern for human well-being. Thus, there is great demand for a continuous supply of novel antibiotics to combat this problem. Bacteria-derived antimicrobial peptides (AMPs) have long been used as food preservatives; moreover, prior to the development of conventional antibiotics, these AMPs served as an efficient source of antibiotics. Recently, peptides produced by members of the genus Bacillus were shown to have a broad spectrum of antimicrobial activity against pathogenic microbes. Bacillus-derived AMPs can be synthesized both ribosomally and nonribosomally and can be classified according to peptide biosynthesis, structure, and molecular weight. The precise mechanism of action of these AMPs is not yet clear; however, one proposed mechanism is that these AMPs kill bacteria by forming channels in and (or) disrupting the bacterial cell wall. Bacillus-derived AMPs have potential in the pharmaceutical industry, as well as the food and agricultural sectors. Here, we focus on Bacillus-derived AMPs as a novel alternative approach to antibacterial drug development. We also provide an overview of the biosynthesis, mechanisms of action, applications, and effectiveness of different AMPs produced by members of the Bacillus genus, including several recently identified novel AMPs. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS | - |
dc.title | Antimicrobial peptides of the genus Bacillus: a new era for antibiotics | - |
dc.type | Article | - |
dc.identifier.doi | 10.1139/cjm-2014-0613 | - |
dc.identifier.bibliographicCitation | CANADIAN JOURNAL OF MICROBIOLOGY, v.61, no.2, pp 93 - 103 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000349326400002 | - |
dc.identifier.scopusid | 2-s2.0-84922323689 | - |
dc.citation.endPage | 103 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 93 | - |
dc.citation.title | CANADIAN JOURNAL OF MICROBIOLOGY | - |
dc.citation.volume | 61 | - |
dc.type.docType | Review | - |
dc.publisher.location | 캐나다 | - |
dc.subject.keywordAuthor | antibiotics | - |
dc.subject.keywordAuthor | antibiotic resistance | - |
dc.subject.keywordAuthor | antimicrobial peptides | - |
dc.subject.keywordAuthor | Bacillus species | - |
dc.subject.keywordPlus | NEWLY IDENTIFIED BACTERIOCIN | - |
dc.subject.keywordPlus | AMINO-ACID-SEQUENCE | - |
dc.subject.keywordPlus | PARTIAL-PURIFICATION | - |
dc.subject.keywordPlus | ANTIFUNGAL PROTEIN | - |
dc.subject.keywordPlus | SUBTILIS STRAIN | - |
dc.subject.keywordPlus | ANTIBACTERIAL ACTIVITY | - |
dc.subject.keywordPlus | CLOSTRIDIUM-DIFFICILE | - |
dc.subject.keywordPlus | INHIBITORY-ACTIVITY | - |
dc.subject.keywordPlus | NATURAL-PRODUCTS | - |
dc.subject.keywordPlus | THURINGIENSIS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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