Optical Coherence Tomographic Observation of In-Stent Neoatherosclerosis in Lesions With More Than 50% Neointimal Area Stenosis After Second-Generation Drug-Eluting Stent Implantation
DC Field | Value | Language |
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dc.contributor.author | Lee, Seung-Yul | - |
dc.contributor.author | Hur, Seung-Ho | - |
dc.contributor.author | Lee, Sang-Gon | - |
dc.contributor.author | Kim, Sang-Wook | - |
dc.contributor.author | Shin, Dong-Ho | - |
dc.contributor.author | Kim, Jung-Sun | - |
dc.contributor.author | Kim, Byeong-Keuk | - |
dc.contributor.author | Ko, Young-Guk | - |
dc.contributor.author | Choi, Donghoon | - |
dc.contributor.author | Jang, Yangsoo | - |
dc.contributor.author | Hong, Myeong-Ki | - |
dc.date.available | 2019-03-08T17:59:15Z | - |
dc.date.issued | 2015-02 | - |
dc.identifier.issn | 1941-7640 | - |
dc.identifier.issn | 1941-7632 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9929 | - |
dc.description.abstract | Background-Despite the enhanced properties of the second-generation drug-eluting stent (DES), its association with neoatherosclerosis has not been sufficiently evaluated. Therefore, we sought to evaluate and compare neoatherosclerosis in second-generation DESs to first-generation DESs. Methods and Results-A total of 212 DES-treated patients with >50% percent neointimal cross-sectional area stenosis were retrospectively enrolled from the Korean multicenter optical coherence tomography (OCT) registry. Within this population, 111 patients had a second-generation DES (40 zotarolimus, 36 everolimus, and 35 biolimus) and 101 patients had a first-generation (65 sirolimus and 36 paclitaxel) DES. Neoatherosclerosis on OCT was defined as neointima formation with the presence of lipids or calcification. OCT-determined neoatherosclerosis was identified in 27.4% (58/212) of all DES-treated lesions. The frequency of neoatherosclerosis increased with the stent age. Stent age was shorter in the second-generation DES group (12.4 months versus 55.4 months, P<0.001), and neoatherosclerosis was less frequently observed in that group (10.8% versus 45.5%, P<0.001). However, after adjusting for cardiovascular risk factors, chronic kidney disease (odds ratio, 4.113; 95% confidence interval, 1.086-15.575; P=0.037), >70 mg/dL of low-density cholesterol at follow-up OCT (odds ratio, 2.532; 95% confidence interval, 1.054-6.084; P=0.038), and stent age (odds ratio, 1.710; 95% confidence interval, 1.403-2.084; P<0.001) were all independent predictors for neoatherosclerosis, whereas the type of DES (first-versus second-generation) was not. Patients with neoatherosclerosis showed a higher rate of acute coronary syndrome at follow-up OCT (19.0% versus 3.9%, respectively, P=0.001). Conclusions-The second-generation DES is not more protective against neoatherosclerosis compared with the first-generation DES. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | Optical Coherence Tomographic Observation of In-Stent Neoatherosclerosis in Lesions With More Than 50% Neointimal Area Stenosis After Second-Generation Drug-Eluting Stent Implantation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1161/CIRCINTERVENTIONS.114.001878 | - |
dc.identifier.bibliographicCitation | CIRCULATION-CARDIOVASCULAR INTERVENTIONS, v.8, no.2 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000349804000013 | - |
dc.identifier.scopusid | 2-s2.0-84925875316 | - |
dc.citation.number | 2 | - |
dc.citation.title | CIRCULATION-CARDIOVASCULAR INTERVENTIONS | - |
dc.citation.volume | 8 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | atherosclerosis | - |
dc.subject.keywordAuthor | drug-eluting stent | - |
dc.subject.keywordAuthor | optical coherence tomography | - |
dc.subject.keywordPlus | BARE-METAL STENTS | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | RESTENOSIS | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | THROMBOSIS | - |
dc.subject.keywordPlus | PATHOLOGY | - |
dc.subject.keywordPlus | REGISTRY | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | HUMANS | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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