The effect of sequential therapy with lansoprazole and ecabet sodium in treating iatrogenic gastric ulcer after endoscopic submucosal dissection: A randomized prospective study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ahn, Ji Yong | - |
dc.contributor.author | Choi, Chang Hwan | - |
dc.contributor.author | Lee, Jang Wook | - |
dc.contributor.author | Park, Sung Jin | - |
dc.contributor.author | Kim, Jeong Wook | - |
dc.contributor.author | Chang, Sae Kyung | - |
dc.contributor.author | Han, Seung Bong | - |
dc.date.available | 2019-03-08T17:59:23Z | - |
dc.date.issued | 2015-02 | - |
dc.identifier.issn | 1751-2972 | - |
dc.identifier.issn | 1751-2980 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/9935 | - |
dc.description.abstract | ObjectiveEcabet sodium (ES) is a new non-systemic anti-ulcer agent belonging to the category of gastroprotective agents. In this study we aimed to compare the efficacy of a combination therapy with lansoprazole (LS) followed by ES with LS alone in treating endoscopic submucosal dissection (ESD)-induced iatrogenic gastric ulcers. MethodsPatients diagnosed with gastric adenomas or early gastric cancer were randomly divided into either the LS group (30mg once daily for 4 weeks; n=45) or the LS+ES group (LS 30mg once daily for one week followed byES 1500mg twice daily for 3 weeks; n=45). Four weeks after ESD, a follow-up endoscopy was conducted to evaluate the proportions of ulcer reduction and ulcer stages in the two groups. ResultsIn all, 79 patients were included in the final analyses. Both treatment modalities were well-tolerated in most patients, with a drug compliance of over 80%. There were no significant differences between the two groups in terms of the proportions of ulcer reduction (0.95030.1215 in the LS group vs 0.9192 +/- 0.0700 in the LS+ES group, P=0.169) or ulcer stage (P=0.446). The prevalence of adverse events related to drugs and bleeding were also similar between the two groups. ConclusionSequential therapy with LS+ES is as effective as LS alone against ESD-induced gastric ulcers. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | The effect of sequential therapy with lansoprazole and ecabet sodium in treating iatrogenic gastric ulcer after endoscopic submucosal dissection: A randomized prospective study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/1751-2980.12214 | - |
dc.identifier.bibliographicCitation | JOURNAL OF DIGESTIVE DISEASES, v.16, no.2, pp 75 - 82 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000350306000004 | - |
dc.identifier.scopusid | 2-s2.0-84923275274 | - |
dc.citation.endPage | 82 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 75 | - |
dc.citation.title | JOURNAL OF DIGESTIVE DISEASES | - |
dc.citation.volume | 16 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | ecabet sodium | - |
dc.subject.keywordAuthor | endoscopic submucosal dissection | - |
dc.subject.keywordAuthor | lansoprazole | - |
dc.subject.keywordAuthor | stomach neoplasm | - |
dc.subject.keywordAuthor | stomach ulcer | - |
dc.subject.keywordPlus | HELICOBACTER-PYLORI STATUS | - |
dc.subject.keywordPlus | MONOSODIUM SALT TA-2711 | - |
dc.subject.keywordPlus | PROTON PUMP INHIBITOR | - |
dc.subject.keywordPlus | MUCOSAL RESECTION | - |
dc.subject.keywordPlus | CONTROLLED-TRIAL | - |
dc.subject.keywordPlus | ANTIULCER DRUG | - |
dc.subject.keywordPlus | OMEPRAZOLE | - |
dc.subject.keywordPlus | AGENT | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | FAMOTIDINE | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.