Determination of eurycomanone in rat plasma using hydrophilic interaction liquid chromatography-tandem mass spectrometry for pharmacokinetic study
DC Field | Value | Language |
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dc.contributor.author | Rehman, Shaheed Ur | - |
dc.contributor.author | Choi, Min Sun | - |
dc.contributor.author | Han, Young Min | - |
dc.contributor.author | Kim, In Sook | - |
dc.contributor.author | Kim, Seung Hyun | - |
dc.contributor.author | Piao, Xiang-Lan | - |
dc.contributor.author | Yoo, Hye Hyun | - |
dc.date.accessioned | 2021-06-22T14:22:54Z | - |
dc.date.available | 2021-06-22T14:22:54Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2017-04 | - |
dc.identifier.issn | 0269-3879 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/10058 | - |
dc.description.abstract | In this study, a rapid, sensitive, and reliable hydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC-MS/MS) method for the determination of eurycomanone in rat plasma was developed and validated. Plasma samples were pretreated with a protein precipitation method and quercitrin was used as an internal standard (IS). A HILIC silica column (2.1x100mm, 3m) was used for hydrophilic-based chromatographic separation, using the mobile phase of 0.1% formic acid with acetonitrile in gradient elution at a flow rate of 0.25mL/min. Precursor-product ion pairs for multiple-reaction monitoring were m/z 409.1391.0 for eurycomanone and m/z 449.1303.0 for IS. The linear range was 2-120ng/mL. The intra- and inter-day accuracies were between 95.5 and 103.4% with a precision of <4.2%. The developed method was successfully applied to the pharmacokinetic analysis of eurycomanone in rat plasma after oral dosing with pure compound and E. longifolia extract. The C-max and AUC(0-t), respectively, were 40.43 +/- 16.08ng/mL and 161.09 +/- 37.63ngh/mL for 10mg/kg eurycomanone, and 9.90 +/- 3.97ng/mL and 37.15 +/- 6.80ngh/mL for E. longifolia extract (2mg/kg as eurycomanone). The pharmacokinetic results were comparable with each other, based on the dose as eurycomanone. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | Determination of eurycomanone in rat plasma using hydrophilic interaction liquid chromatography-tandem mass spectrometry for pharmacokinetic study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Hye Hyun | - |
dc.identifier.doi | 10.1002/bmc.3831 | - |
dc.identifier.scopusid | 2-s2.0-84992446141 | - |
dc.identifier.wosid | 000399300900003 | - |
dc.identifier.bibliographicCitation | Biomedical Chromatography, v.31, no.4, pp.1 - 8 | - |
dc.relation.isPartOf | Biomedical Chromatography | - |
dc.citation.title | Biomedical Chromatography | - |
dc.citation.volume | 31 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | INDONESIAN MEDICINAL-PLANTS | - |
dc.subject.keywordPlus | LONGIFOLIA JACK | - |
dc.subject.keywordPlus | TONGKAT ALI | - |
dc.subject.keywordPlus | ANTIMALARIAL CONSTITUENTS | - |
dc.subject.keywordPlus | MAJOR QUASSINOIDS | - |
dc.subject.keywordPlus | ROOTS | - |
dc.subject.keywordPlus | SPERMATOGENESIS | - |
dc.subject.keywordPlus | BIOAVAILABILITY | - |
dc.subject.keywordPlus | ALKALOIDS | - |
dc.subject.keywordPlus | MALAYSIA | - |
dc.subject.keywordAuthor | Eurycoma longifolia | - |
dc.subject.keywordAuthor | eurycomanone | - |
dc.subject.keywordAuthor | HILIC-MS | - |
dc.subject.keywordAuthor | MS | - |
dc.subject.keywordAuthor | pharmacokinetics | - |
dc.subject.keywordAuthor | plasma | - |
dc.identifier.url | https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/bmc.3831 | - |
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