Phage-Based Structural Color Sensors and Their Pattern Recognition Sensing System
- Authors
- Lee, Ju Hun; Fan, Benson; Samdin, Tuan D.; Monteiro, David A.; Desai, Malav S.; Scheideler, Olivia; Jin, Hyo-Eon; Kim, Soyoun; Lee, Seung-Wuk
- Issue Date
- Apr-2017
- Publisher
- American Chemical Society
- Keywords
- M13 bacteriophage; columnar smectic phase; cross-reactive; structural color; biomimetics; biosensor; olfactory system
- Citation
- ACS Nano, v.11, no.4, pp.3632 - 3641
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACS Nano
- Volume
- 11
- Number
- 4
- Start Page
- 3632
- End Page
- 3641
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/10068
- DOI
- 10.1021/acsnano.6b07942
- ISSN
- 1936-0851
- Abstract
- The mammalian olfactory system provides great inspiration for the design of intelligent sensors. To this end, we have developed a bioinspired phage nanostructure-based color sensor array and a smartphonebased sensing network system. Using a M13 bacteriophage (phage) as a basic building block, we created structural color matrices that are composed of liquid-crystalline bundled nanofibers from self-assembled phages. The phages were engineered to express cross-responsive receptors on their major coat protein (pVIII), leading to rapid, detectable color changes upon exposure to various target chemicals, resulting in chemical- and concentration-dependent color fingerprints. Using these sensors, we have successfully detected 5-90% relative humidity with 0.2% sensitivity. In addition, after modification with aromatic receptors, we were able to distinguish between various structurally similar toxic chemicals including benzene, toluene, xylene, and aniline. Furthermore, we have developed a method of interpreting and disseminating results from these sensors using smartphones to establish a wireless system. Our phage-based sensor system has the potential to be very useful in improving national security and monitoring the environment and human health.
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