Development of Bioactive PEGylated Nanostructured Platforms for Sequential Delivery of Doxorubicin and Imatinib to Overcome Drug Resistance in Metastatic Tumors
DC Field | Value | Language |
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dc.contributor.author | Gupta, Biki | - |
dc.contributor.author | Ramasamy, Thiruganesh | - |
dc.contributor.author | Poudel, Bijay Kumar | - |
dc.contributor.author | Pathak, Shiva | - |
dc.contributor.author | Regmi, Shobha | - |
dc.contributor.author | Choi, Ju Yeon | - |
dc.contributor.author | Son, Youlim | - |
dc.contributor.author | Thapa, Raj Kumar | - |
dc.contributor.author | Jeong, Jee-Heon | - |
dc.contributor.author | Kim, Jae Ryong | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.contributor.author | Yong, Chul Soon | - |
dc.contributor.author | Kim, Jong Oh | - |
dc.date.accessioned | 2021-06-22T14:23:19Z | - |
dc.date.available | 2021-06-22T14:23:19Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2017-03 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/10078 | - |
dc.description.abstract | Metastasis of cancers accounts for almost all cancer-related deaths. In this study, we report a PEGylated nanostructured platform for coadministration of doxorubicin (DOX) and imatinib (IMT) intended to effectively inhibit metastatic tumors. The DOX and IMT coloaded nanostructured system (DOX/IMT-N) is characterized by an excellent encapsulation potential for both drugs and shows sequential and sustained drug release in vitro. DOX/IMT-N significantly inhibited the in vitro proliferation of MDA-MB-231 and SK-MEL-28 cells. The inhibitory effect on in vitro proliferation of the cells was significantly greater than the effect of free DOX, DOX/IMT cocktail, or the nanostructured system housing DOX only (DOX-N). DOX/IMT-N remarkably enhanced cellular drug uptake, resulting in enhanced apoptosis, caused by significant increases in the expression levels of apoptotic marker proteins. Intravenous administration of DOX/IMT-N to MBA-MB-231 xenograft tumor-bearing mice resulted in significantly improved inhibition of tumor progression compared to that with DOX, DOX/IMT, or DOX-N. Therefore, the nanostructured DOX/IMT-N system could potentially aid in overcoming drug resistance in metastatic tumors and improve the effectiveness of metastatic tumor therapeutics. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Development of Bioactive PEGylated Nanostructured Platforms for Sequential Delivery of Doxorubicin and Imatinib to Overcome Drug Resistance in Metastatic Tumors | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Han-Gon | - |
dc.identifier.doi | 10.1021/acsami.6b09163 | - |
dc.identifier.scopusid | 2-s2.0-85016006338 | - |
dc.identifier.wosid | 000397478100012 | - |
dc.identifier.bibliographicCitation | ACS APPLIED MATERIALS & INTERFACES, v.9, no.11, pp.9280 - 9290 | - |
dc.relation.isPartOf | ACS APPLIED MATERIALS & INTERFACES | - |
dc.citation.title | ACS APPLIED MATERIALS & INTERFACES | - |
dc.citation.volume | 9 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 9280 | - |
dc.citation.endPage | 9290 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | SOLID LIPID NANOPARTICLES | - |
dc.subject.keywordPlus | PHASE-III TRIAL | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | MULTIDRUG-RESISTANCE | - |
dc.subject.keywordPlus | P-GLYCOPROTEIN | - |
dc.subject.keywordPlus | INCREASED EXPRESSION | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | CARRIERS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CHEMORESISTANCE | - |
dc.subject.keywordAuthor | metastasis | - |
dc.subject.keywordAuthor | doxorubicin | - |
dc.subject.keywordAuthor | imatinib | - |
dc.subject.keywordAuthor | nanostructured platform | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordAuthor | chemoresistance | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/acsami.6b09163 | - |
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