Layer-by-layer assembly of hierarchical nanoarchitectures to enhance the systemic performance of nanoparticle albumin-bound paclitaxel
DC Field | Value | Language |
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dc.contributor.author | Ruttala, Hima Bindu | - |
dc.contributor.author | Ramasamy, Thiruganesh | - |
dc.contributor.author | Shin, Beom Soo | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.contributor.author | Yong, Chul Soon | - |
dc.contributor.author | Kim, Jong Oh | - |
dc.date.accessioned | 2021-06-22T14:23:30Z | - |
dc.date.available | 2021-06-22T14:23:30Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2017-03 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/10087 | - |
dc.description.abstract | Although protein-bound paclitaxel (PTX, Abraxane (R)) has been established as a standard PTX-based therapy against multiple cancers, its clinical success is limited by unfavorable pharmacokinetics, suboptimal biodistribution, and acute toxicities. In the present study, we aimed to apply the principles of a layer-by-layer(LbL) technique to improve the poor colloidal stability and pharmacokinetic pattern of nanoparticle albumin-bound paclitaxel (nab-PTX). LbL-based nab-PTX was successfully fabricated by the alternate deposition of polyarginine (pARG) and poly(ethylene glycol)-block-poly(L-aspartic acid) (PEGb-PLD) onto an albumin conjugate. The presence of protective entanglement by polyamino acids prevented the dissociation of nab-PTX and improved its colloidal stability even at a 100-fold dilution. The combined effect of high nanoparticle internalization and controlled release of PTX from LbL-nab-PTX increased its cytotoxicity in MCF-7 and MDA-MB-231 breast cancer cells. LbL-nab-PTX consistently induced apoptosis in approximately 52% and 22% of MCF-7 and MDA-MB-231 cancer cells, respectively. LbL assembly of polypeptides effectively prevented exposure of PTX to the systemic environment and thereby inhibited drug-induced hemolysis. Most importantly, LbL assembly of polypeptides to nab-PTX effectively increased the blood circulation potential of PTX and improved therapeutic efficacy via a significantly higher area under the curve (AUC)(0-infinity). We report for the first time the application of LbL functional architectures for improving the systemic performance of nab-PTX with a view toward its clinical translation for cancer therapy. (C) 2017 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Layer-by-layer assembly of hierarchical nanoarchitectures to enhance the systemic performance of nanoparticle albumin-bound paclitaxel | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Han-Gon | - |
dc.identifier.doi | 10.1016/j.ijpharm.2017.01.011 | - |
dc.identifier.scopusid | 2-s2.0-85008936647 | - |
dc.identifier.wosid | 000398005400002 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.519, no.1-2, pp.11 - 21 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.citation.title | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.citation.volume | 519 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 11 | - |
dc.citation.endPage | 21 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | ANTITUMOR EFFICACY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | MICELLES | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | CHITOSAN | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | IRINOTECAN | - |
dc.subject.keywordPlus | TAXANE | - |
dc.subject.keywordAuthor | Albumin | - |
dc.subject.keywordAuthor | Nanoparticle | - |
dc.subject.keywordAuthor | Colloidal stability | - |
dc.subject.keywordAuthor | Systemic performance | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S037851731730011X?via%3Dihub | - |
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