Cell-Free Hydrogel System Based on a Tissue-Specific Extracellular Matrix for In Situ Adipose Tissue Regeneration
DC Field | Value | Language |
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dc.contributor.author | Kim, Jun Sung | - |
dc.contributor.author | Choi, Ji Suk | - |
dc.contributor.author | Cho, Yong Woo | - |
dc.date.accessioned | 2021-06-22T14:23:33Z | - |
dc.date.available | 2021-06-22T14:23:33Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2017-03 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/10090 | - |
dc.description.abstract | Well-designed scaffolds provide appropriate niches that can effectively recruit host cells and induce differentiation of recruited cells into the desired cell types, facilitating in situ tissue regeneration. Here we report a tissue-specific extracellular matrix (ECM) hydrogel composed of adipose-derived soluble ECM (sECM) and methylcellulose (MC) as a cell-free scaffold system for adipose tissue regeneration. The sECM MC hydrogels showed a thermosensitive sol-gel phase transition and rapidly formed a soft hydrogel with a stiffness of 3.8 kPa at body temperature. An in vivo study showed that the sECM MC hydrogel facilitated the infiltration of host cell populations, particularly adipose-derived stem cells (ASCs) and adipose tissue macrophages (ATMs) that directly contribute to the adipose tissue regeneration. Moreover, the hydrogel significantly enhanced host-derived adipogenesis and angiogenesis without exogenous cells or bioactive molecules. Our results indicate that the sECM MC hydrogels provide mechanical and biochemical cues for host-derived adipose regeneration. Overall, the sECM MC hydrogels are a highly promising cell-free therapeutic approach for in situ adipose tissue regeneration. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Cell-Free Hydrogel System Based on a Tissue-Specific Extracellular Matrix for In Situ Adipose Tissue Regeneration | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Yong Woo | - |
dc.identifier.doi | 10.1021/acsami.6b16783 | - |
dc.identifier.scopusid | 2-s2.0-85015456011 | - |
dc.identifier.wosid | 000396801200017 | - |
dc.identifier.bibliographicCitation | ACS APPLIED MATERIALS & INTERFACES, v.9, no.10, pp.8581 - 8588 | - |
dc.relation.isPartOf | ACS APPLIED MATERIALS & INTERFACES | - |
dc.citation.title | ACS APPLIED MATERIALS & INTERFACES | - |
dc.citation.volume | 9 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 8581 | - |
dc.citation.endPage | 8588 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | PROGENITOR CELLS | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | FAT PAD | - |
dc.subject.keywordPlus | STIFFNESS | - |
dc.subject.keywordPlus | ADIPOGENESIS | - |
dc.subject.keywordPlus | SCAFFOLDS | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordAuthor | in situ adipose tissue regeneration | - |
dc.subject.keywordAuthor | cell-free scaffold system | - |
dc.subject.keywordAuthor | adipose-derived soluble extracellular matrix | - |
dc.subject.keywordAuthor | thermosensitive extracellular matrix hydrogel | - |
dc.subject.keywordAuthor | host cell recruitment | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/acsami.6b16783 | - |
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