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Advancing host-directed therapy for tuberculosis: new therapeutic insights from the Toxoplasma gondiiopen access
- Authors
- Yang, Chul-Su
- Issue Date
- Mar-2017
- Publisher
- Shared Science Publishers OG
- Keywords
- Macrophages; Mycobacterium tuberculosis; Protein-protein interactions; Toxoplasma gondii GRA7
- Citation
- Microbial Cell, v.4, no.3, pp 105 - 107
- Pages
- 3
- Indexed
- SCOPUS
ESCI
- Journal Title
- Microbial Cell
- Volume
- 4
- Number
- 3
- Start Page
- 105
- End Page
- 107
- ISSN
- 2311-2638
- Abstract
- Tuberculosis (TB) drug-development strategies, a wide range of candidate host-directed therapies (HDT) sincluding new and repurposed drugs, biologics, and cellular therapies-have been proposed to accelerate eradication of infection and overcome the problems associated with current treatment regimens. By investigating the interaction between macrophages and the intracellular parasite Toxoplasma gondii (T. gondii), we uncovered that infection-induced signaling pathways suggest possibilities for the development of novel therapeutic modalities for TB that target the intracellular signaling pathways permitting the replication of Mycobacterium tuberculosis (MTB).
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Related Researcher
- Yang, Chul Su
- ERICA 첨단융합대학 (ERICA 분자의약전공)