Bioelectronic Skin Based on Nociceptive Ion Channel for Human-Like Perception of Cold Pains
DC Field | Value | Language |
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dc.contributor.author | Shin, Narae | - |
dc.contributor.author | Lee, Seung Hwan | - |
dc.contributor.author | Cho, Youngtak | - |
dc.contributor.author | Park, Tai Hyun | - |
dc.contributor.author | Hong, Seunghun | - |
dc.date.accessioned | 2021-06-22T09:03:18Z | - |
dc.date.available | 2021-06-22T09:03:18Z | - |
dc.date.issued | 2020-07 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.issn | 1613-6829 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/1013 | - |
dc.description.abstract | A bioelectronic skin device based on nociceptive ion channels in nanovesicles is developed for the detection of chemical cold-pain stimuli and cold environments just like human somesthetic sensory systems. The human transient receptor potential ankyrin 1 (hTRPA1) is involved in transmission and modulation of cold-pain sensations. In the bioelectronic skin, the nanovesicles containing the hTRPA1 nociceptive ion channel protein reacts to cold-pain stimuli, and it is electrically monitored through carbon nanotube transistor devices based on floating electrodes. The bioelectronic skin devices sensitively detect chemical cold-pain stimuli like cinnamaldehyde at 10 fm, and selectively discriminate cinnamaldehyde among other chemical stimuli. Further, the bioelectronic skin is used to evaluate the effect of cold environments on the response of the hTRPA1, finding that the nociceptive ion channel responds more sensitively to cinnamaldehyde at lower temperatures than at higher temperatures. The bioelectronic skin device could be useful for a basic study on somesthetic systems such as cold-pain sensation, and should be used for versatile applications such as screening of foods and drugs. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Wiley - V C H Verlag GmbbH & Co. | - |
dc.title | Bioelectronic Skin Based on Nociceptive Ion Channel for Human-Like Perception of Cold Pains | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1002/smll.202001469 | - |
dc.identifier.scopusid | 2-s2.0-85087170754 | - |
dc.identifier.wosid | 000544308800001 | - |
dc.identifier.bibliographicCitation | Small, v.16, no.30, pp 1 - 7 | - |
dc.citation.title | Small | - |
dc.citation.volume | 16 | - |
dc.citation.number | 30 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 7 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | SULFHYDRYL-GROUPS | - |
dc.subject.keywordPlus | TASTE RECEPTOR | - |
dc.subject.keywordPlus | TRPA1 | - |
dc.subject.keywordPlus | SENSOR | - |
dc.subject.keywordPlus | 2-IMINOTHIOLANE | - |
dc.subject.keywordPlus | DISCRIMINATION | - |
dc.subject.keywordPlus | SUGGESTS | - |
dc.subject.keywordPlus | REAGENT | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordAuthor | bioelectronic skins | - |
dc.subject.keywordAuthor | carbon nanotube field-effect transistors | - |
dc.subject.keywordAuthor | cinnamaldehyde | - |
dc.subject.keywordAuthor | human transient receptor potential ankyrin 1 | - |
dc.subject.keywordAuthor | nociceptive ion channels | - |
dc.subject.keywordAuthor | nanovesicles | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/smll.202001469 | - |
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