BJ-3105, a 6-Alkoxypyridin-3-ol Analog, Impairs T Cell Differentiation and Prevents Experimental Autoimmune Encephalomyelitis Disease Progression
DC Field | Value | Language |
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dc.contributor.author | Timilshina, Maheshwor | - |
dc.contributor.author | Kang, Youra | - |
dc.contributor.author | Dahal, Ishmit | - |
dc.contributor.author | You, Zhiwei | - |
dc.contributor.author | Nam, Tae-Gyu | - |
dc.contributor.author | Kim, Keuk-Jun | - |
dc.contributor.author | Jeong, Byeong-Seon | - |
dc.contributor.author | Chang, Jae-Hoon | - |
dc.date.accessioned | 2021-06-22T14:41:59Z | - |
dc.date.available | 2021-06-22T14:41:59Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/10532 | - |
dc.description.abstract | CD4(+) T cells are essential in inflammation and autoimmune diseases. Interferon-gamma (IFN-gamma) secreting T helper (Th1) and IL-17 secreting T helper (Th17) cells are critical for several autoimmune diseases. To assess the inhibitory effect of a given compound on autoimmune disease, we screened many compounds with an in vitro Th differentiation assay. BJ-3105, a 6-alkoxypyridin-3-ol analog, inhibited IFN-gamma and IL-17 production from polyclonal CD4(+) T cells and ovalbumin (OVA)-specific CD4(+) T cells which were activated by T cell receptor (TCR) engagement. BJ-3105 ameliorated the experimental autoimmune encephalomyelitis (EAE) model by reducing Th1 and Th17 generation. Notably, Th cell differentiation was significantly suppressed by BJ-3105 treatment without inhibiting in vitro proliferation of T cells or inducing programmed cell death. Mechanistically, BJ-3105 inhibited the phosphorylation of JAK and its downstream signal transducer and activator of transcription (STAT) that is critical for Th differentiation. These results demonstrated that BJ-3105 inhibits the phosphorylation of STAT in response to cytokine signals and subsequently suppressed the differentiation of Th cell responses. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | BJ-3105, a 6-Alkoxypyridin-3-ol Analog, Impairs T Cell Differentiation and Prevents Experimental Autoimmune Encephalomyelitis Disease Progression | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Nam, Tae-Gyu | - |
dc.identifier.doi | 10.1371/journal.pone.0168942 | - |
dc.identifier.scopusid | 2-s2.0-85009811782 | - |
dc.identifier.wosid | 000392372300012 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.12, no.1, pp.1 - 18 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 18 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | MULTIPLE-SCLEROSIS | - |
dc.subject.keywordPlus | IMMUNE DEVIATION | - |
dc.subject.keywordPlus | TH17 CELL | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | GM-CSF | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | IL-17 | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordAuthor | MULTIPLE-SCLEROSIS | - |
dc.subject.keywordAuthor | ENCEPHALITOGENIC ANTIGENS | - |
dc.subject.keywordAuthor | IMMUNE DEVIATION | - |
dc.subject.keywordAuthor | TH17 CELLS | - |
dc.subject.keywordAuthor | IN-VIVO | - |
dc.subject.keywordAuthor | GM-CSF | - |
dc.subject.keywordAuthor | CYTOKINES | - |
dc.subject.keywordAuthor | IL-17 | - |
dc.subject.keywordAuthor | PATHOGENESIS | - |
dc.subject.keywordAuthor | INDUCTION | - |
dc.identifier.url | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168942 | - |
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