Preparation and Characterization of a Lutein Solid Dispersion to Improve Its Solubility and Stability
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Chaemin | - |
dc.contributor.author | Kang, Jin Kook | - |
dc.contributor.author | Jung, Chan Eun | - |
dc.contributor.author | Sim, Taehoon | - |
dc.contributor.author | Her, Jaewon | - |
dc.contributor.author | Kang, Kioh | - |
dc.contributor.author | Lee, Eun Seong | - |
dc.contributor.author | Youn, Yu Seok | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.contributor.author | Oh, Kyung Taek | - |
dc.date.accessioned | 2021-07-28T08:10:13Z | - |
dc.date.available | 2021-07-28T08:10:13Z | - |
dc.date.created | 2021-07-14 | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 1530-9932 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/105768 | - |
dc.description.abstract | Lutein has been used as a dietary supplement for the treatment of eye diseases, especially age-related macular degeneration. For oral formulations, we investigated lutein stability in artificial set-ups mimicking different physiological conditions and found that lutein was degraded over time under acidic conditions. To enhance the stability of lutein upon oral intake, we developed enteric-coated lutein solid dispersions (SD) by applying a polymer, hydroxypropyl methylcellulose acetate succinate (HPMCAS-LF), through a solvent-controlled precipitation method. The SD were characterized in crystallinity, morphology, and drug entrapment. In the dissolution profile of lutein SD, a F80 formulation showed resistance toward the acidic environment under simulated gastric conditions while exhibiting a bursting drug release under simulated intestinal conditions. Our results highlight the potential use of HPMCAS-LF as an effective matrix to enhance lutein bioavailability during oral delivery and to provide novel insights into the eye-care supplement industry, with direct benefits for the health of patients. Graphical abstract: [Figure not available: see fulltext.]. © 2021, American Association of Pharmaceutical Scientists. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Springer Science and Business Media Deutschland GmbH | - |
dc.title | Preparation and Characterization of a Lutein Solid Dispersion to Improve Its Solubility and Stability | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Han-Gon | - |
dc.identifier.doi | 10.1208/s12249-021-02036-4 | - |
dc.identifier.scopusid | 2-s2.0-85107152944 | - |
dc.identifier.wosid | 000765803400001 | - |
dc.identifier.bibliographicCitation | AAPS PharmSciTech, v.22, no.5, pp.1 - 9 | - |
dc.relation.isPartOf | AAPS PharmSciTech | - |
dc.citation.title | AAPS PharmSciTech | - |
dc.citation.volume | 22 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ZEAXANTHIN | - |
dc.subject.keywordPlus | EYE | - |
dc.subject.keywordPlus | BIOAVAILABILITY | - |
dc.subject.keywordPlus | FORMULATION | - |
dc.subject.keywordPlus | MIXTURES | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | SHELL | - |
dc.subject.keywordAuthor | absorption | - |
dc.subject.keywordAuthor | bioavailability | - |
dc.subject.keywordAuthor | degradation | - |
dc.subject.keywordAuthor | lutein | - |
dc.subject.keywordAuthor | oral drug delivery | - |
dc.subject.keywordAuthor | pH sensitivity | - |
dc.subject.keywordAuthor | solid dispersion | - |
dc.subject.keywordAuthor | stability | - |
dc.identifier.url | https://link.springer.com/article/10.1208%2Fs12249-021-02036-4 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Korea+82-31-400-4269 sweetbrain@hanyang.ac.kr
COPYRIGHT © 2021 HANYANG UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.