Mycobacterium abscessus ESX-3 plays an important role in host inflammatory and pathological responses during infection
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Yi Sak | - |
dc.contributor.author | Yang, Chul-Su | - |
dc.contributor.author | Nguyen, Loi T. | - |
dc.contributor.author | Kim, Jin Kyung | - |
dc.contributor.author | Jin, Hyo Sun | - |
dc.contributor.author | Choe, Jin ho | - |
dc.contributor.author | Kim, Soo Yeon | - |
dc.contributor.author | Lee, Hye-Mi | - |
dc.contributor.author | Jung, Mingyu | - |
dc.contributor.author | Kim, Jin-Man | - |
dc.contributor.author | Kim, Myung Hee | - |
dc.contributor.author | Jo, Eun-Kyeong | - |
dc.contributor.author | Jang, Ji-Chan | - |
dc.date.accessioned | 2021-06-22T14:43:04Z | - |
dc.date.available | 2021-06-22T14:43:04Z | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 1286-4579 | - |
dc.identifier.issn | 1769-714X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/10584 | - |
dc.description.abstract | Mycobacterial ESX systems are often related to pathogenesis during infection. However, little is known about the function of ESX systems of Mycobacterhun abscessus (Mab). This study focuses on the Mab ESX-3 cluster, which contains major genes such as esxH (Rv0288, low molecular weight protein antigen 7; CFP-7) and esxG (Rv0287, ESAT-6 like protein). An esx-3 (MAB 2224c-2234c)-deletional mutant of Mab (Delta esx) was constructed and used to infect murine and human macrophages. We then investigated whether Mab Delta esx modulated innate host immune responses in macrophages. Mab Delta esx infection resulted in less pathological and inflammatory responses. Additionally, Delta esx resulted in significantly decreased activation of inflammatory signaling and cytokine production in macrophages compared to WT. Moreover, recombinant EsxG.EsxH (rEsxGH) proteins encoded by the ESX-3 region showed synergistic enhancement of inflammatory cytokine generation in macrophages infected with Delta esx. Taken together, our data suggest that Mab ESX-3 plays an important role in inflammatory and pathological responses during Mab infection. (C) 2016 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved. | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Mycobacterium abscessus ESX-3 plays an important role in host inflammatory and pathological responses during infection | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.micinf.2016.09.001 | - |
dc.identifier.scopusid | 2-s2.0-84998567500 | - |
dc.identifier.wosid | 000392677400002 | - |
dc.identifier.bibliographicCitation | Microbes and Infection, v.19, no.1, pp 5 - 17 | - |
dc.citation.title | Microbes and Infection | - |
dc.citation.volume | 19 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 5 | - |
dc.citation.endPage | 17 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | INNATE IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTORS | - |
dc.subject.keywordPlus | FACTOR-ALPHA | - |
dc.subject.keywordPlus | SECRETION SYSTEM | - |
dc.subject.keywordPlus | TUBERCULOSIS | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | ESAT-6 | - |
dc.subject.keywordPlus | TLR2 | - |
dc.subject.keywordAuthor | Mycobacterium abscessus | - |
dc.subject.keywordAuthor | ESX-3 | - |
dc.subject.keywordAuthor | Host inflammation | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S128645791630123X?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Korea+82-31-400-4269 sweetbrain@hanyang.ac.kr
COPYRIGHT © 2021 HANYANG UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.