PE_PGRS38 Interaction With HAUSP Downregulates Antimycobacterial Host Defense via TRAF6
DC Field | Value | Language |
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dc.contributor.author | Kim, Jae-Sung | - |
dc.contributor.author | Kim, Hyo Keun | - |
dc.contributor.author | Cho, Euni | - |
dc.contributor.author | Mun, Seok-Jun | - |
dc.contributor.author | Jang, Sein | - |
dc.contributor.author | Jang, Jichan | - |
dc.contributor.author | Yang, Chul-Su | - |
dc.date.accessioned | 2022-07-18T01:16:29Z | - |
dc.date.available | 2022-07-18T01:16:29Z | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/107887 | - |
dc.description.abstract | Mycobacterium tuberculosis (Mtb) is the causative pathogen of tuberculosis (TB), which manipulates the host immunity to ensure survival and colonization in the host. Mtb possess a unique family of proteins, named PE_PGRS, associated with Mtb pathogenesis. Thus, elucidation of the functions of PE_PGRS proteins is necessary to understand TB pathogenesis. Here, we investigated the role of PE_PGRS38 binding to herpesvirus-associated ubiquitin-specific protease (HAUSP, USP7) in regulating the activity of various substrate proteins by modulating their state of ubiquitination. We constructed the recombinant PE_PGRS38 expressed in M. smegmatis (Ms_PE_PGRS38) to investigate the role of PE_PGRS38. We found that Ms_PE_PGRS38 regulated the cytokine levels in murine bone marrow-derived macrophages by inhibiting the deubiquitination of tumor necrosis factor receptor-associated factor (TRAF) 6 by HAUSP. Furthermore, the PE domain in PE_PGRS38 was identified as essential for mediating TRAF6 deubiquitination. Ms_PE_PGRS38 increased the intracellular burden of bacteria by manipulating cytokine levels in vitro and in vivo. Overall, we revealed that the interplay between HAUSP and PE_PGRS38 regulated the inflammatory response to increase the survival of mycobacteria. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Frontiers Media S.A. | - |
dc.title | PE_PGRS38 Interaction With HAUSP Downregulates Antimycobacterial Host Defense via TRAF6 | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3389/fimmu.2022.862628 | - |
dc.identifier.scopusid | 2-s2.0-85130022419 | - |
dc.identifier.wosid | 000794338900001 | - |
dc.identifier.bibliographicCitation | Frontiers in Immunology, v.13, pp 1 - 12 | - |
dc.citation.title | Frontiers in Immunology | - |
dc.citation.volume | 13 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 12 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | UBIQUITIN-SPECIFIC PROTEASE | - |
dc.subject.keywordPlus | PE-PGRS PROTEINS | - |
dc.subject.keywordPlus | MYCOBACTERIUM-TUBERCULOSIS | - |
dc.subject.keywordPlus | INTRACELLULAR SURVIVAL | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | SMEGMATIS | - |
dc.subject.keywordPlus | MACROPHAGE | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | DEUBIQUITINASE | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordAuthor | Mycobacterium tuberculosis PE_PGRS38 | - |
dc.subject.keywordAuthor | Mycobacterium smegmatis | - |
dc.subject.keywordAuthor | HAUSP | - |
dc.subject.keywordAuthor | TRAF6 | - |
dc.subject.keywordAuthor | Macrophages | - |
dc.subject.keywordAuthor | Ubiquitination | - |
dc.identifier.url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.862628/full | - |
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