Neuroprotective efficacy of N-t-butylhydroxylamine (NtBHA) in transient focal ischemia in rats
DC Field | Value | Language |
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dc.contributor.author | Kim, Eun-Sun | - |
dc.contributor.author | Shin, Yusun | - |
dc.contributor.author | Kim, Eun-Hye | - |
dc.contributor.author | Kim, Donghyun | - |
dc.contributor.author | De Felice, Milena | - |
dc.contributor.author | Majid, Arshad | - |
dc.contributor.author | Bae, Ok-Nam | - |
dc.date.accessioned | 2022-07-18T01:16:56Z | - |
dc.date.available | 2022-07-18T01:16:56Z | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 1976-8257 | - |
dc.identifier.issn | 2234-2753 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/107898 | - |
dc.description.abstract | The pharmacological or toxicological activities of the degradation products of drug candidates have been unaddressed during the drug development process. Ischemic stroke accounts for 80% of all strokes and is responsible for considerable mortality and disability worldwide. Despite decades of research on neuroprotective agents, tissue plasminogen activators (t-PA), a thrombolytic agent, remains the only approved acute stroke pharmacological therapy. NXY-059, a free radical scavenger, exhibited striking neuroprotective properties in preclinical models and met all the criteria established by the Stroke Academic Industry Roundtable (STAIR) for a neuroprotective agent. In phase 3 clinical trials, NXY-059 exhibited significant neuroprotective effects in one trial (SAINT-I), but not in the second (SAINT-II). Some have hypothesized that N-t-butyl hydroxylamine (NtBHA), a breakdown product of NXY-059 was the actual neuroprotective agent in SAINT-I and that changes to the formulation of NXY-059 to prevent its breakdown to NtBHA in SAINT -II was the reason for the lack of efficacy. We evaluated the neuroprotective effect of NtBHA in N-methyl-D-aspartate (NMDA)-treated primary neurons and in rat focal cerebral ischemia. NtBHA significantly attenuated infarct volume in rat transient focal ischemia, and attenuated NMDA-induced cytotoxicity in primary cortical neurons. NtBHA also reduced free radical generation and exhibited mitochondrial protection. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국독성학회 | - |
dc.title | Neuroprotective efficacy of N-t-butylhydroxylamine (NtBHA) in transient focal ischemia in rats | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.1007/s43188-022-00131-7 | - |
dc.identifier.scopusid | 2-s2.0-85128055388 | - |
dc.identifier.wosid | 000782533700001 | - |
dc.identifier.bibliographicCitation | Toxicological Research, v.38, no.4, pp 479 - 486 | - |
dc.citation.title | Toxicological Research | - |
dc.citation.volume | 38 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 479 | - |
dc.citation.endPage | 486 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002886173 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | CEREBRAL-ISCHEMIA | - |
dc.subject.keywordPlus | BUTYL HYDROXYLAMINE | - |
dc.subject.keywordPlus | SAINT-I | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | POOLED ANALYSIS | - |
dc.subject.keywordPlus | ACUTE STROKE | - |
dc.subject.keywordPlus | NXY-059 | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | OCCLUSION | - |
dc.subject.keywordPlus | TOLERABILITY | - |
dc.subject.keywordAuthor | Ischemic stroke | - |
dc.subject.keywordAuthor | Neuroprotection | - |
dc.subject.keywordAuthor | N-t-butylhydroxylamine (NtBHA) | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s43188-022-00131-7 | - |
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