Lysophosphatidylserine Induces MUC5AC Production via the Feedforward Regulation of the TACE-EGFR-ERK Pathway in Airway Epithelial Cells in a Receptor-Independent Manner
DC Field | Value | Language |
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dc.contributor.author | Sim, Myeong Seong | - |
dc.contributor.author | Kim, Hye Jeong | - |
dc.contributor.author | Jo, Sang Hee | - |
dc.contributor.author | Kim, Chun | - |
dc.contributor.author | Chung, Il Yup | - |
dc.date.accessioned | 2022-07-18T01:17:22Z | - |
dc.date.available | 2022-07-18T01:17:22Z | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/107910 | - |
dc.description.abstract | Lysophosphatidylserine (LysoPS) is an amphipathic lysophospholipid that mediates a broad spectrum of inflammatory responses through a poorly characterized mechanism. Because LysoPS levels can rise in a variety of pathological conditions, we sought to investigate LysoPS's potential role in airway epithelial cells that actively participate in lung homeostasis. Here, we report a previously unappreciated function of LysoPS in production of a mucin component, MUC5AC, in the airway epithelial cells. LysoPS stimulated lung epithelial cells to produce MUC5AC via signaling pathways involving TACE, EGFR, and ERK. Specifically, LysoPS- dependent biphasic activation of ERK resulted in TGF-alpha secretion and strong EGFR phosphorylation leading to MUC5AC production. Collectively, LysoPS induces the expression of MUC5AC via a feedback loop composed of proligand synthesis and its proteolysis by TACE and following autocrine EGFR activation. To our surprise, we were not able to find a role of GPCRs and TLR2, known LysoPS receptors in LysoPS-induced MUC5AC production in airway epithelial cells, suggesting a potential receptor-independent action of LysoPS during inflammation. This study provides new insight into the potential function and mechanism of LysoPS as an emerging lipid mediator in airway inflammation. | - |
dc.format.extent | 17 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Lysophosphatidylserine Induces MUC5AC Production via the Feedforward Regulation of the TACE-EGFR-ERK Pathway in Airway Epithelial Cells in a Receptor-Independent Manner | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/ijms23073866 | - |
dc.identifier.scopusid | 2-s2.0-85127217771 | - |
dc.identifier.wosid | 000780656700001 | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Sciences, v.23, no.7, pp 1 - 17 | - |
dc.citation.title | International Journal of Molecular Sciences | - |
dc.citation.volume | 23 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 17 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | ALPHA-CONVERTING ENZYME | - |
dc.subject.keywordPlus | GROWTH-FACTOR RECEPTOR | - |
dc.subject.keywordPlus | MUCUS HYPERSECRETION | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | MUCIN EXPRESSION | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | CASCADE | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | ROLES | - |
dc.subject.keywordAuthor | airway epithelial cells | - |
dc.subject.keywordAuthor | EGFR | - |
dc.subject.keywordAuthor | MUC5AC | - |
dc.subject.keywordAuthor | LysoPS | - |
dc.subject.keywordAuthor | TACE | - |
dc.subject.keywordAuthor | TGF-alpha | - |
dc.subject.keywordAuthor | TLR2 | - |
dc.identifier.url | https://www.mdpi.com/1422-0067/23/7/3866 | - |
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