Analysis of multi-omics data on the relationship between epigenetic changes and nervous system disorders caused by exposure to environmentally harmful substances
DC Field | Value | Language |
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dc.contributor.author | Yu, So Yeon | - |
dc.contributor.author | Koh, Eun Jung | - |
dc.contributor.author | Kim, Seung Hwan | - |
dc.contributor.author | Song, Byeongwook | - |
dc.contributor.author | Lee, Ji Su | - |
dc.contributor.author | Son, Sang Wook | - |
dc.contributor.author | Seo, Hyemyung | - |
dc.contributor.author | Hwang, Seung Yong | - |
dc.date.accessioned | 2022-07-18T01:28:03Z | - |
dc.date.available | 2022-07-18T01:28:03Z | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 1520-4081 | - |
dc.identifier.issn | 1522-7278 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/108083 | - |
dc.description.abstract | Environmentally hazardous substances and exposure to these can cause various diseases. Volatile organic compounds can easily evaporate into the atmosphere, thereby exerting toxic effects through either the skin or respiratory tract exposures. Toluene, a neurotoxin, has been widely used in various industries. However, it has a detrimental effect on the nervous system (such as hallucinations or memory impairment), while data on the mechanism underlaying its harmful effects remain limited. Therefore, this study investigates the effect of toluene on the nervous system via epigenetic and genetic changes of toluene-exposed individuals. We identified significant epigenetic changes and confirmed that the affected abnormally expressed genes negatively influenced the nervous system. In particular, we confirmed that the miR-15 family, upregulated by toluene, downregulated ABL2, which could affect the R as signaling pathway resulting in neuronal structural abnormalities. Our study suggests that miR-15a-5p, miR-15b-5p, miR-16-5p, miR-301a-3p, and lncRNA NEAT1 may represent effective epigenomic markers associated with neurodegenerative diseases caused by toluene. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | Analysis of multi-omics data on the relationship between epigenetic changes and nervous system disorders caused by exposure to environmentally harmful substances | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1002/tox.23444 | - |
dc.identifier.scopusid | 2-s2.0-85121417486 | - |
dc.identifier.wosid | 000731298400001 | - |
dc.identifier.bibliographicCitation | Environmental Toxicology, v.37, no.4, pp 802 - 813 | - |
dc.citation.title | Environmental Toxicology | - |
dc.citation.volume | 37 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 802 | - |
dc.citation.endPage | 813 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalResearchArea | Water Resources | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Water Resources | - |
dc.subject.keywordPlus | LONG NONCODING RNAS | - |
dc.subject.keywordPlus | DNA METHYLATION | - |
dc.subject.keywordPlus | DENDRITIC SPINE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | TOLUENE | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | NEAT1 | - |
dc.subject.keywordPlus | MEG3 | - |
dc.subject.keywordAuthor | epigenetic | - |
dc.subject.keywordAuthor | neurodegenerative diseases | - |
dc.subject.keywordAuthor | noncoding RNA | - |
dc.subject.keywordAuthor | Ras signaling | - |
dc.subject.keywordAuthor | toluene | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/tox.23444 | - |
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