Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson's Disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Schweitzer, Jeffrey S. | - |
dc.contributor.author | Song, Bin | - |
dc.contributor.author | Herrington, Todd M. | - |
dc.contributor.author | Park, Tae-Yoon | - |
dc.contributor.author | Lee, Nayeon | - |
dc.contributor.author | Ko, Sanghyeok | - |
dc.contributor.author | Jeon, Jeha | - |
dc.contributor.author | Cha, Young | - |
dc.contributor.author | Kim, Kyungsang | - |
dc.contributor.author | Li, Quanzheng | - |
dc.contributor.author | Henchcliffe, Claire | - |
dc.contributor.author | Kaplitt, Michael | - |
dc.contributor.author | Neff, Carolyn | - |
dc.contributor.author | Rapalino, Otto | - |
dc.contributor.author | SEO, HYE MYUNG | - |
dc.contributor.author | Lee, In-Hee | - |
dc.contributor.author | Kim, Jisun | - |
dc.contributor.author | Kim, Taewoo | - |
dc.contributor.author | Petsko, Gregory A. | - |
dc.contributor.author | Ritz, Jerome | - |
dc.contributor.author | Cohen, Bruce M. | - |
dc.contributor.author | Kong, Sek-Won | - |
dc.contributor.author | Leblanc, Pierre | - |
dc.contributor.author | Carter, Bob S. | - |
dc.contributor.author | Kim, Kwang-Soo | - |
dc.date.accessioned | 2021-06-22T09:04:25Z | - |
dc.date.available | 2021-06-22T09:04:25Z | - |
dc.date.created | 2021-02-18 | - |
dc.date.issued | 2020-05 | - |
dc.identifier.issn | 0028-4793 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/1100 | - |
dc.description.abstract | We report the implantation of patient-derived midbrain dopaminergic progenitor cells, differentiated in vitro from autologous induced pluripotent stem cells (iPSCs), in a patient with idiopathic Parkinson’s disease. The patient-specific progenitor cells were produced under Good Manufacturing Practice conditions and characterized as having the phenotypic properties of substantia nigra pars compacta neurons; testing in a humanized mouse model (involving peripheral-blood mononuclear cells) indicated an absence of immunogenicity to these cells. The cells were implanted into the putamen (left hemisphere followed by right hemisphere, 6 months apart) of a patient with Parkinson’s disease, without the need for immunosuppression. Positron-emission tomography with the use of fluorine-18-L-dihydroxyphenylalanine suggested graft survival. Clinical measures of symptoms of Parkinson’s disease after surgery stabilized or improved at 18 to 24 months after implantation. Copyright © 2020 Massachusetts Medical Society. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Massachusetts Medical Society | - |
dc.title | Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson's Disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | SEO, HYE MYUNG | - |
dc.identifier.doi | 10.1056/NEJMoa1915872 | - |
dc.identifier.scopusid | 2-s2.0-85084626323 | - |
dc.identifier.wosid | 000535944700021 | - |
dc.identifier.bibliographicCitation | New England Journal of Medicine, v.382, no.20, pp.1926 - 1932 | - |
dc.relation.isPartOf | New England Journal of Medicine | - |
dc.citation.title | New England Journal of Medicine | - |
dc.citation.volume | 382 | - |
dc.citation.number | 20 | - |
dc.citation.startPage | 1926 | - |
dc.citation.endPage | 1932 | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | GRAFTS | - |
dc.identifier.url | https://www.nejm.org/doi/full/10.1056/NEJMoa1915872 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Korea+82-31-400-4269 sweetbrain@hanyang.ac.kr
COPYRIGHT © 2021 HANYANG UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.