Plk2-mediated phosphorylation and translocalization of Nrf2 activates anti-inflammation through p53/Plk2/p21(cip1) signaling in acute kidney injury
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Da-Eun | - |
dc.contributor.author | Byeon, Hye Eun | - |
dc.contributor.author | Kim, Dae-Hoon | - |
dc.contributor.author | Kim, Sang Geon | - |
dc.contributor.author | Yim, Hyungshin | - |
dc.date.accessioned | 2022-10-07T12:00:56Z | - |
dc.date.available | 2022-10-07T12:00:56Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.issn | 0742-2091 | - |
dc.identifier.issn | 1573-6822 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/111005 | - |
dc.description.abstract | The Plk2 is a cellular stress-responsive factor that is induced in response to oxidative stress. However, the roles of Plk2 in acute kidney injury (AKI) have not been clarified. We previously found that Plk2 is an interacting factor of Nrf2 in response to cellular stress, since Plk2 is upregulated in the Nrf2-dependent network. Here, we show that the levels of p53, Plk2, p21(cip1), and chromatin-bound Nrf2 were all upregulated in kidney tissues of mice or NRK52E cells treated with either cisplatin or methotrexate. Upregulation of Plk2 by p53 led to an increase of Nrf2 in both soluble and chromatin fractions in cisplatin-treated NRK52E cells. Consistently, depletion of Plk2 suppressed the levels of Nrf2. Of note, Plk2 directly phosphorylated Nrf2 at Ser40, which facilitated its interaction with p21(cip1) and translocation into the nuclei for the activation of anti-oxidative and anti-inflammatory factors in response to AKI. Together, these findings suggest that Plk2 may serve as an anti-oxidative and anti-inflammatory regulator through the phosphorylation and activation of Nrf2 to protect kidney cells from kidney toxicants and that Plk2 and Nrf2 therefore work cooperatively for the protection and survival of kidney cells from harmful stresses. | - |
dc.format.extent | 21 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Springer | - |
dc.title | Plk2-mediated phosphorylation and translocalization of Nrf2 activates anti-inflammation through p53/Plk2/p21(cip1) signaling in acute kidney injury | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1007/s10565-022-09741-1 | - |
dc.identifier.scopusid | 2-s2.0-85134549587 | - |
dc.identifier.wosid | 000826136200001 | - |
dc.identifier.bibliographicCitation | Cell Biology and Toxicology, v.39, no.4, pp 1509 - 1529 | - |
dc.citation.title | Cell Biology and Toxicology | - |
dc.citation.volume | 39 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1509 | - |
dc.citation.endPage | 1529 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | POLO-LIKE KINASE | - |
dc.subject.keywordPlus | ANTIOXIDANT RESPONSE ELEMENT | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR NRF2 | - |
dc.subject.keywordPlus | CENTRIOLE DUPLICATION | - |
dc.subject.keywordPlus | MOLECULAR-MECHANISMS | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | PLK2 | - |
dc.subject.keywordAuthor | Plk2 | - |
dc.subject.keywordAuthor | Nrf2 | - |
dc.subject.keywordAuthor | p53 | - |
dc.subject.keywordAuthor | Anti-inflammation | - |
dc.subject.keywordAuthor | Acute kidney injury | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s10565-022-09741-1 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Korea+82-31-400-4269 sweetbrain@hanyang.ac.kr
COPYRIGHT © 2021 HANYANG UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.