Foldable Detergents for Membrane Protein Stability
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Youn, Taeyeol | - |
dc.contributor.author | Yoon, Soyoung | - |
dc.contributor.author | Byrne, Bernadette | - |
dc.contributor.author | Chae, Pil Seok | - |
dc.date.accessioned | 2022-12-20T05:53:22Z | - |
dc.date.available | 2022-12-20T05:53:22Z | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 1439-4227 | - |
dc.identifier.issn | 1439-7633 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/111366 | - |
dc.description.abstract | Detergents are widely used for membrane protein structural study. Many recently developed detergents contain multiple tail and head groups, which are typically connected via a small and branched linker. Due to their inherent compact structures, with small inter-alkyl chain distances, these detergents form micelles with high alkyl chain density in the interiors, a feature favorably associated with membrane-protein stability. A recent study on tandem triazine maltosides (TZMs) revealed a distinct trend; despite possession of an apparently large inter-alkyl chain distance, the TZM-Es were highly effective at stabilizing membrane proteins. Thanks to the incorporation of a flexible spacer between the two triazine rings in the linker region, these detergents are prone to folding into a compact architecture in micellar environments instead of adopting an extended conformation. Detergent foldability represents a new concept of novel detergent design with significant potential for future detergent development. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | John Wiley & Sons Ltd. | - |
dc.title | Foldable Detergents for Membrane Protein Stability | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1002/cbic.202200276 | - |
dc.identifier.scopusid | 2-s2.0-85133306505 | - |
dc.identifier.wosid | 000820590100001 | - |
dc.identifier.bibliographicCitation | ChemBioChem, v.23, no.19, pp 1 - 5 | - |
dc.citation.title | ChemBioChem | - |
dc.citation.volume | 23 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 5 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.subject.keywordPlus | MALTOSIDE AMPHIPHILES | - |
dc.subject.keywordPlus | CRYSTALLIZATION | - |
dc.subject.keywordPlus | SOLUBILIZATION | - |
dc.subject.keywordPlus | STABILIZATION | - |
dc.subject.keywordAuthor | amphiphiles | - |
dc.subject.keywordAuthor | foldable detergents | - |
dc.subject.keywordAuthor | membrane proteins | - |
dc.subject.keywordAuthor | protein stabilization | - |
dc.subject.keywordAuthor | self-assembly | - |
dc.identifier.url | https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202200276 | - |
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