Chemical constituents of the Ajuga multiflora bunge and their protective effects on dexamethasone-induced muscle atrophy in C2C12 myotubes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yunjung | - |
dc.contributor.author | Kim, Hye Mi | - |
dc.contributor.author | Kim, Ji Hoon | - |
dc.contributor.author | Lee, Ju-Hee | - |
dc.contributor.author | Zhang, Kai Xuan | - |
dc.contributor.author | Gao, En Mei | - |
dc.contributor.author | Jeon, Je-Seung | - |
dc.contributor.author | Syed, Ahmed Shah | - |
dc.contributor.author | Son, Rak Ho | - |
dc.contributor.author | Kim, Jae-Yong | - |
dc.contributor.author | Kim, Chul Young | - |
dc.date.accessioned | 2023-02-21T05:36:06Z | - |
dc.date.available | 2023-02-21T05:36:06Z | - |
dc.date.issued | 2023-06 | - |
dc.identifier.issn | 1478-6419 | - |
dc.identifier.issn | 1478-6427 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/111477 | - |
dc.description.abstract | Ajuga multiflora Bunge is a perennial ornamental herb and has been used for the treatment of fever in Korean folk medicine. In the course of searching for protective agents associated with the potential of A. multiflora against dexamethsone (DEX)-induced muscle atrophy, a new phytoecdysteroid, 29-hydroxyprecyasterone (1), together with four known compounds (2-5), were isolated from A. multiflora. The structures of the compounds were determined by spectroscopic analyses, including 1D-, 2D-NMR and HR-MS interpretation. To elucidate the effects of obtained compounds on DEX-induced muscle atrophy, the myotubes diameter, myosin heavy chain (MyHC) positive area, and fusion index were evaluated by immunofluorescence staining. Overall, each compound treatment effectively prevented the atrophic myotubes through an increase of MyHC-positive myotubes and the number of nuclei. Particularly, the measurement of myotube diameter showed that compounds 1 and 5 treatment significantly alleviated the myotube thickness. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Taylor & Francis | - |
dc.title | Chemical constituents of the Ajuga multiflora bunge and their protective effects on dexamethasone-induced muscle atrophy in C2C12 myotubes | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1080/14786419.2022.2115491 | - |
dc.identifier.scopusid | 2-s2.0-85136813677 | - |
dc.identifier.wosid | 000844089900001 | - |
dc.identifier.bibliographicCitation | Natural Product Research, v.37, no.12, pp 1 - 9 | - |
dc.citation.title | Natural Product Research | - |
dc.citation.volume | 37 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 9 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.subject.keywordPlus | MYOBLASTS | - |
dc.subject.keywordPlus | L. | - |
dc.subject.keywordAuthor | Ajuga multiflora Bunge | - |
dc.subject.keywordAuthor | 29-hydroxyprecyasterone | - |
dc.subject.keywordAuthor | dexamethasone | - |
dc.subject.keywordAuthor | muscle atrophy | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/14786419.2022.2115491 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Korea+82-31-400-4269 sweetbrain@hanyang.ac.kr
COPYRIGHT © 2021 HANYANG UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.