Salvia plebeia R.Br. and Rosmarinic Acid Attenuate Dexamethasone-Induced Muscle Atrophy in C2C12 Myotubes
DC Field | Value | Language |
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dc.contributor.author | Kim, Jae-Yong | - |
dc.contributor.author | Kim, Hye Mi | - |
dc.contributor.author | Kim, Ji Hoon | - |
dc.contributor.author | Guo, Shuo | - |
dc.contributor.author | Lee, Do Hyun | - |
dc.contributor.author | Lim, Gyu Min | - |
dc.contributor.author | Kim, Wondong | - |
dc.contributor.author | Kim, Chul Young | - |
dc.date.accessioned | 2023-05-03T09:36:32Z | - |
dc.date.available | 2023-05-03T09:36:32Z | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/112609 | - |
dc.description.abstract | Skeletal muscle atrophy occurs when protein degradation exceeds protein synthesis and is associated with increased circulating glucocorticoid levels. Salvia plebeia R.Br. (SPR) has been used as herbal remedy for a variety of inflammatory diseases and has various biological actions such as antioxidant and anti-inflammatory activities. However, there are no reports on the effects of SPR and its bioactive components on muscle atrophy. Herein, we investigated the anti-atrophic effect of SPR and rosmarinic acid (RosA), a major compound of SPR, on dexamethasone (DEX)-induced skeletal muscle atrophy in C2C12 myotubes. Myotubes were treated with 10 mu M DEX in the presence or absence of SPR or RosA at different concentrations for 24 h and subjected to immunocytochemistry, western blot, and measurements of ROS and ATP levels. SPR and RosA increased viability and inhibited protein degradation in DEX-treated C2C12 myotubes. In addition, RosA promoted the Akt/p70S6K/mTOR pathway and reduced ROS production, and apoptosis. Furthermore, the treatment of RosA significantly recovered SOD activity, autophagy activity, mitochondrial contents, and APT levels in DEX-treated myotubes. These findings suggest that SPR and RosA may provide protective effects against DEX-induced muscle atrophy and have promising potential as a nutraceutical remedy for the treatment of muscle weakness and atrophy. | - |
dc.format.extent | 16 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Salvia plebeia R.Br. and Rosmarinic Acid Attenuate Dexamethasone-Induced Muscle Atrophy in C2C12 Myotubes | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/ijms24031876 | - |
dc.identifier.scopusid | 2-s2.0-85147895439 | - |
dc.identifier.wosid | 000931083600001 | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Sciences, v.24, no.3, pp 1 - 16 | - |
dc.citation.title | International Journal of Molecular Sciences | - |
dc.citation.volume | 24 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 16 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | EXERCISE | - |
dc.subject.keywordAuthor | Salvia plebeia R.Br. | - |
dc.subject.keywordAuthor | Rosmarinic acid | - |
dc.subject.keywordAuthor | dexamethasone | - |
dc.subject.keywordAuthor | atrophy | - |
dc.subject.keywordAuthor | C2C12 | - |
dc.identifier.url | https://www.mdpi.com/1422-0067/24/3/1876 | - |
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