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Deciphering the therapeutic mechanism of topical WS2 nanosheets for the effective therapy of burn injuries

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dc.contributor.authorSo, Yoonhee-
dc.contributor.authorYim, DaBin-
dc.contributor.authorSon, Wooic-
dc.contributor.authorLee, Hyunji-
dc.contributor.authorLee, Sin-
dc.contributor.authorChoi, Chanhee-
dc.contributor.authorYang, Chul Su-
dc.contributor.authorKim, Jong-Ho-
dc.date.accessioned2023-05-03T09:47:59Z-
dc.date.available2023-05-03T09:47:59Z-
dc.date.issued2022-12-
dc.identifier.issn2352-9407-
dc.identifier.urihttps://scholarworks.bwise.kr/erica/handle/2021.sw.erica/112780-
dc.description.abstractDeep burn injuries are complicated traumas accompanying severe oxidative stress and impairment of inherent cellular defense mechanisms against external bacteria. Accordingly, it is required to suppress oxidative stress and support the recovery of intrinsic defense systems in burn wound lesions, but limited topical treatments are clinically available. Herein, antioxidative and anti-inflammatory 2H-WS2 nanosheets are developed as a biocompatible, topical antipyrotic for the treatment of deep burn wounds. The 2H-WS2 nanosheets functional-ized with a block copolymer can effectively suppress extrinsic apoptosis, lipid peroxidation, and inflammation in human keratinocytes by scavenging intracellular reactive oxygen species (ROS) and reactive nitrogen species (RNS). Moreover, the 2H-WS2 nanosheets markedly stimulate the up-regulation of innate antioxidant enzymes and antimicrobial peptides in the skin cells, enhancing their intrinsic cellular defense systems. The combined effects of this 2H-WS2 antipyrotic enables a higher efficacy in the deep burn wounds of mice, accelerating re-epithelialization and satisfactory wound healing as compared with commercial silver sulfadiazine (SSD). The therapeutic mechanism of the 2H-WS2 nanosheets for deep burn wounds is proposed herein and found to be distinctly different from that of SSD. The nanotherapeutics of multifunctional 2H-WS2 nanosheets show potential for use in the treatment of other oxidative stress-induced and inflammatory diseases.-
dc.format.extent13-
dc.language영어-
dc.language.isoENG-
dc.publisherElsevier BV-
dc.titleDeciphering the therapeutic mechanism of topical WS2 nanosheets for the effective therapy of burn injuries-
dc.typeArticle-
dc.publisher.location네델란드-
dc.identifier.doi10.1016/j.apmt.2022.101591-
dc.identifier.scopusid2-s2.0-85134852699-
dc.identifier.wosid000836149500002-
dc.identifier.bibliographicCitationApplied Materials Today, v.29, pp 1 - 13-
dc.citation.titleApplied Materials Today-
dc.citation.volume29-
dc.citation.startPage1-
dc.citation.endPage13-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaMaterials Science-
dc.relation.journalWebOfScienceCategoryMaterials Science, Multidisciplinary-
dc.subject.keywordPlusTRANSITION-METAL DICHALCOGENIDES-
dc.subject.keywordPlusSILVER SULFADIAZINE-
dc.subject.keywordPlusOXIDATIVE STRESS-
dc.subject.keywordPlusSKIN-
dc.subject.keywordPlusWOUNDS-
dc.subject.keywordPlusEXFOLIATION-
dc.subject.keywordPlusNANOPARTICLES-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusMOLECULES-
dc.subject.keywordPlusINFECTION-
dc.subject.keywordAuthorAnti -inflammation-
dc.subject.keywordAuthorAnti-apoptosis-
dc.subject.keywordAuthorBurn wound healing-
dc.subject.keywordAuthorOxidative stress suppression-
dc.subject.keywordAuthorWS2 nanosheet antipyrotic-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S2352940722002256?via%3Dihub-
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COLLEGE OF ENGINEERING SCIENCES > DEPARTMENT OF MATERIALS SCIENCE AND CHEMICAL ENGINEERING > 1. Journal Articles
COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY > ERICA 의약생명과학과 > 1. Journal Articles

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ERICA 공학대학 (DEPARTMENT OF MATERIALS SCIENCE AND CHEMICAL ENGINEERING)
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