Cauliflower-like platinum nanostructures mediated photothermal and colorimetric dual-readout biosensor for sensitive cholesterol detection
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gupta, Pramod K. | - |
dc.contributor.author | Son, Seong Eun | - |
dc.contributor.author | Venkatesan, Jayachandran | - |
dc.contributor.author | Seong, Gi Hun | - |
dc.date.accessioned | 2023-07-05T05:45:53Z | - |
dc.date.available | 2023-07-05T05:45:53Z | - |
dc.date.issued | 2023-07 | - |
dc.identifier.issn | 0925-4005 | - |
dc.identifier.issn | 0925-4005 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/113312 | - |
dc.description.abstract | Point-of-care testing has been extensively utilized for in-home diagnosis, customized testing, and pandemic monitoring. The current study aims to develop a nanozyme-mediated dual-readout (colorimetric and photo -thermal) bioassay for straightforward and sensitive detection of cholesterol. The nanozyme, cauliflower-like platinum nanostructures (CS@Pt NS) were synthesized by chemically reducing the Pt precursor in the chito-san (CS) solution. CS as a stabilizer excels at controlling the surface properties, enhancing peroxidase-like ac-tivity, and improving colloidal dispersion, and stability. The dual-readout sensor for cholesterol detection was proposed by combining cholesterol oxidase-catalyzed cholesterol oxidation with CS@Pt NS-catalyzed TMB oxidation. The oxidized TMB (TMBox) acts as a probe for both colorimetric and photothermal readouts because of having excellent absorbance in visible and near-infrared (NIR) regions. The absorption of NIR laser-driven light by the TMBox in the reaction solution generates heat, which is proportional to the concentration of cholesterol. The dual-readout sensor shows a linear detection range of 0-2 mM, with a limit of detection (LOD) of 45 mu M for the colorimetric assay and 25 mu M for the photothermal assay. Furthermore, the sensor successfully detects cholesterol in spiked human serum with acceptable accuracy. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Cauliflower-like platinum nanostructures mediated photothermal and colorimetric dual-readout biosensor for sensitive cholesterol detection | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.1016/j.snb.2023.133741 | - |
dc.identifier.scopusid | 2-s2.0-85161124936 | - |
dc.identifier.wosid | 000978795900001 | - |
dc.identifier.bibliographicCitation | Sensors and Actuators, B: Chemical, v.386, pp 1 - 10 | - |
dc.citation.title | Sensors and Actuators, B: Chemical | - |
dc.citation.volume | 386 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 10 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Electrochemistry | - |
dc.relation.journalResearchArea | Instruments & Instrumentation | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.relation.journalWebOfScienceCategory | Electrochemistry | - |
dc.relation.journalWebOfScienceCategory | Instruments & Instrumentation | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordAuthor | Nanozymes | - |
dc.subject.keywordAuthor | Chitosan | - |
dc.subject.keywordAuthor | Platinum nanostructures | - |
dc.subject.keywordAuthor | Dual -readout | - |
dc.subject.keywordAuthor | Photothermal | - |
dc.subject.keywordAuthor | Colorimetric | - |
dc.subject.keywordAuthor | Cholesterol | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0925400523004562 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Korea+82-31-400-4269 sweetbrain@hanyang.ac.kr
COPYRIGHT © 2021 HANYANG UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.