Macrophage-reprogramming upconverting nanoparticles for enhanced TAM-mediated antitumor therapy of hypoxic breast cancer
DC Field | Value | Language |
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dc.contributor.author | Yoon, Johyun | - |
dc.contributor.author | Le, Xuan Thien | - |
dc.contributor.author | Kim, Juho | - |
dc.contributor.author | Lee, Hyunjun | - |
dc.contributor.author | Nguyen, Nguyen Thi | - |
dc.contributor.author | Lee, Woo Tak | - |
dc.contributor.author | Lee, Eun Seong | - |
dc.contributor.author | Oh, Kyung Taek | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.contributor.author | Youn, Yu Seok | - |
dc.date.accessioned | 2023-08-01T06:31:51Z | - |
dc.date.available | 2023-08-01T06:31:51Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.issn | 1873-4995 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/113613 | - |
dc.description.abstract | In an attempt to achieve antitumor effects by switching the phenotype of macrophages from the tumor-promoting M2 type to the tumor-suppressing M1 type, we fabricated mannose-decorated/macrophage membrane–coated, silica-layered NaErF4@NaLuF4 upconverting nanoparticles (UCNPs) co-doped with perfluorocarbon (PFC)/chlorin e6 (Ce6) and loaded with paclitaxel (PTX) (UCNP@mSiO2-PFC/Ce6@RAW-Man/PTX: ∼61 nm; −11.6 mV). These nanoparticles were designed to have two major functionalities, (i) efficient singlet oxygen generation aided by an oxygen supply and (ii) good targeting to tumor-associated macrophage (TAMs) (M2-type), to induce polarization to M1 type macrophages that release proinflammatory cytokines and suppress breast cancers. The primary UCNPs consisted of lanthanide elements (erbium and lutetium) in a core@shell structure, and they facilely emitted 660 nm light in response to a deep-penetrating 808 nm near-infrared laser. Moreover, the UCNPs@mSiO2-PFC/Ce6@RAW-Man/PTX were able to release O2 and generate 1O2 because of the co-doped PFC/Ce6 and upconversion. Our nanocarriers' excellent uptake to RAW 264.7 macrophage cells (M2 type) and efficient M1-type polarization activity were clearly demonstrated using qRT-PCR and immunofluorescence-based confocal laser scanning microscopy. Our nanocarriers displayed significant cytotoxicity to 4T1 cells in 2D culture and 3D co-culture systems of 4T1/RAW 264.7 cells. More importantly, UCNPs@mSiO2-PFC/Ce6@RAW-Man/PTX (+808 nm laser) noticeably suppressed tumor growth in 4T1-xenografted mice, compared with the other treatment groups (332.4 vs. 709.5–1185.5 mm3). We attribute this antitumor efficacy to the prominent M1-type macrophage polarization caused by our nanocarriers through efficient ROS/O2 generation and targeting of M2-type TAMs via mannose ligands on coated macrophage-membrane. © 2023 | - |
dc.format.extent | 14 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Macrophage-reprogramming upconverting nanoparticles for enhanced TAM-mediated antitumor therapy of hypoxic breast cancer | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.jconrel.2023.07.009 | - |
dc.identifier.scopusid | 2-s2.0-85164694106 | - |
dc.identifier.wosid | 001050011200001 | - |
dc.identifier.bibliographicCitation | Journal of Controlled Release, v.360, pp 482 - 495 | - |
dc.citation.title | Journal of Controlled Release | - |
dc.citation.volume | 360 | - |
dc.citation.startPage | 482 | - |
dc.citation.endPage | 495 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | TUMOR-ASSOCIATED MACROPHAGES | - |
dc.subject.keywordPlus | PHOTODYNAMIC THERAPY | - |
dc.subject.keywordPlus | O-2-EVOLVING NANOPARTICLES | - |
dc.subject.keywordPlus | HUMAN MONOCYTES | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | IN-SITU | - |
dc.subject.keywordPlus | POLARIZATION | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | OXYGEN | - |
dc.subject.keywordPlus | CONVERSION | - |
dc.subject.keywordAuthor | Cancer immunotherapy | - |
dc.subject.keywordAuthor | M2-to-M1 repolarization | - |
dc.subject.keywordAuthor | Photodynamic therapy | - |
dc.subject.keywordAuthor | Tumor-associated macrophage | - |
dc.subject.keywordAuthor | Upconversion nanoparticles | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0168365923004339 | - |
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