Development of rebamipide-loaded spray-dried microsphere using distilled water and meglumine: physicochemical characterization and pharmacokinetics in rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ko, Dae Woong | - |
dc.contributor.author | Cho, Jung Hyun | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.date.accessioned | 2023-08-16T07:35:07Z | - |
dc.date.available | 2023-08-16T07:35:07Z | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 1083-7450 | - |
dc.identifier.issn | 1097-9867 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/113900 | - |
dc.description.abstract | In this study, a novel rebamipide-loaded spray-dried microsphere (RSM) with enhanced drug solubility and oral bioavailability has been developed utilizing meglumine, an alkalizing agent. The influence of carriers on the drug solubility alone, and the solubility and dissolution of the drug in the RSM was investigated. Among the alkalizing agents and hydrophilic polymers tested, meglumine and polyvinyl alcohol (PVA) showed the highest drug solubility and dissolution rate, respectively. Many RSMs were manufactured with various amounts of meglumine and PVA using distilled water, and their drug solubility and dissolution were determined. The physicochemical properties, dissolution and pharmacokinetics of the chosen RSM in rats were assessed compared to the rebamipide powder and commercial tablet. Among the RSMs tested, the one composed of rebamipide, meglumine and PVA at a weight ratio of 3:1.75:6 showed the highest drug solubility and dissolution. This RSM with a smooth spherical form significantly decreased the particle size and modified the amorphous rebamipide. Furthermore, the drug solubility, dissolution, plasma concentrations, AUC and Cmax values of RSM were significantly higher than those of drug powder and commercial tablet. Thus, this RSN system developed with distilled water and meglumine is recommended as an oral water-soluble rebamipide-loaded pharmaceutical product. © 2021 Informa UK Limited, trading as Taylor & Francis Group. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Marcel Dekker Inc. | - |
dc.title | Development of rebamipide-loaded spray-dried microsphere using distilled water and meglumine: physicochemical characterization and pharmacokinetics in rats | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1080/10837450.2021.1924781 | - |
dc.identifier.scopusid | 2-s2.0-85106342063 | - |
dc.identifier.wosid | 000652406600001 | - |
dc.identifier.bibliographicCitation | Pharmaceutical Development and Technology, v.26, no.6, pp 701 - 708 | - |
dc.citation.title | Pharmaceutical Development and Technology | - |
dc.citation.volume | 26 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 701 | - |
dc.citation.endPage | 708 | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | IN-VIVO EVALUATION | - |
dc.subject.keywordPlus | SOLID DISPERSION | - |
dc.subject.keywordPlus | ORAL BIOAVAILABILITY | - |
dc.subject.keywordPlus | SOLUBILITY | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | FORMULATION | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | ABSORPTION | - |
dc.subject.keywordPlus | COMPOUND | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordAuthor | drug solubility | - |
dc.subject.keywordAuthor | meglumine | - |
dc.subject.keywordAuthor | oral bioavailability | - |
dc.subject.keywordAuthor | Rebamipide | - |
dc.subject.keywordAuthor | spray-dried microsphere | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/10837450.2021.1924781 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Korea+82-31-400-4269 sweetbrain@hanyang.ac.kr
COPYRIGHT © 2021 HANYANG UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.