Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney
DC Field | Value | Language |
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dc.contributor.author | Simic, Petra | - |
dc.contributor.author | Kim, Wondong | - |
dc.contributor.author | Zhou, Wen | - |
dc.contributor.author | Pierce, Kerry A. | - |
dc.contributor.author | Chang, Wenhan | - |
dc.contributor.author | Sykes, David B. | - |
dc.contributor.author | Aziz, Najihah B. | - |
dc.contributor.author | Elmariah, Sammy | - |
dc.contributor.author | Ngo, Debby | - |
dc.contributor.author | Pajevic, Paola Divieti | - |
dc.contributor.author | Govea, Nicolas | - |
dc.contributor.author | Kestenbaum, Bryan R. | - |
dc.contributor.author | De Boer, Ian H. | - |
dc.contributor.author | Cheng, Zhiqiang | - |
dc.contributor.author | Christov, Marta | - |
dc.contributor.author | Chun, Jerold | - |
dc.contributor.author | Leaf, David E. | - |
dc.contributor.author | Waikar, Sushrut S. | - |
dc.contributor.author | Tager, Andrew M. | - |
dc.contributor.author | Gerszten, Robert E. | - |
dc.contributor.author | Thadhani, Ravi I. | - |
dc.contributor.author | Clish, Clary B. | - |
dc.contributor.author | Jüppner, Harald | - |
dc.contributor.author | Wein, Marc N. | - |
dc.contributor.author | Rhee, Eugene P. | - |
dc.date.accessioned | 2023-08-16T07:37:17Z | - |
dc.date.available | 2023-08-16T07:37:17Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 0021-9738 | - |
dc.identifier.issn | 1558-8238 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/113943 | - |
dc.description.abstract | Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that controls blood phosphate levels by increasing renal phosphate excretion and reducing 1,25-dihydroxyvitamin D3 [1,25(OH)2D] production. Disorders of FGF23 homeostasis are associated with significant morbidity and mortality, but a fundamental understanding of what regulates FGF23 production is lacking. Because the kidney is the major end organ of FGF23 action, we hypothesized that it releases a factor that regulates FGF23 synthesis. Using aptamer-based proteomics and liquid chromatography-mass spectrometry-based (LC-MS-based) metabolomics, we profiled more than 1600 molecules in renal venous plasma obtained from human subjects. Renal vein glycerol-3-phosphate (G-3-P) had the strongest correlation with circulating FGF23. In mice, exogenous G-3-P stimulated bone and bone marrow FGF23 production through local G-3-P acyltransferase-mediated (GPAT-mediated) lysophosphatidic acid (LPA) synthesis. Further, the stimulatory effect of G-3-P and LPA on FGF23 required LPA receptor 1 (LPAR1). Acute kidney injury (AKI), which increases FGF23 levels, rapidly increased circulating G-3-P in humans and mice, and the effect of AKI on FGF23 was abrogated by GPAT inhibition or Lpar1 deletion. Together, our findings establish a role for kidney-derived G-3-P in mineral metabolism and outline potential targets to modulate FGF23 production during kidney injury. © 2020, American Society for Clinical Investigation. | - |
dc.format.extent | 14 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | American Society for Clinical Investigation | - |
dc.title | Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1172/JCI131190 | - |
dc.identifier.scopusid | 2-s2.0-85081134521 | - |
dc.identifier.wosid | 000544325200047 | - |
dc.identifier.bibliographicCitation | Journal of Clinical Investigation, v.130, no.3, pp 1513 - 1526 | - |
dc.citation.title | Journal of Clinical Investigation | - |
dc.citation.volume | 130 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1513 | - |
dc.citation.endPage | 1526 | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | GROWTH-FACTOR 23 | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | LYSOPHOSPHATIDIC ACID | - |
dc.subject.keywordPlus | HORMONE | - |
dc.subject.keywordPlus | BLOOD | - |
dc.subject.keywordPlus | 1,25-DIHYDROXYVITAMIN-D | - |
dc.subject.keywordPlus | RECRUITMENT | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | REVEALS | - |
dc.identifier.url | https://escholarship.org/uc/item/74z8c4z1 | - |
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