Citric Acid-Functionalized Rhodium−Platinum Nanoparticles as Peroxidase Mimics for Determination of Cholesterol
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Son, Seong Eun | - |
dc.contributor.author | Gupta, Pramod K. | - |
dc.contributor.author | Hur, Won | - |
dc.contributor.author | Lee, Han Been | - |
dc.contributor.author | Park, Yosep | - |
dc.contributor.author | Park, Jiyeon | - |
dc.contributor.author | Kim, Seong Nyeon | - |
dc.contributor.author | Seong, Gi Hun | - |
dc.date.accessioned | 2023-08-16T08:31:11Z | - |
dc.date.available | 2023-08-16T08:31:11Z | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 2574-0970 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/114309 | - |
dc.description.abstract | Nanostructured artificial enzymes, also called nanozymes, are considered effective substitutes for natural enzymes. In this study, citric acid-functionalized rhodium-platinum nanoparticles (CA-RhPt NPs) were synthesized by a simple one-pot synthetic method. Transmission electron microscopy images showed the uniform structure of the CA-RhPt NPs, with an average diameter of 3.5 +/- 0.5 nm, and X-ray photoelectron spectroscopy and zeta potential measurements demonstrated the presence of citric acid in the CA-RhPt NPs. The CA-RhPt NPs exhibited enhanced peroxidase-like activity that catalyzed the reaction between 3,3',5,5'-tetramethylbenzidine (TMB) and hydrogen peroxide (H2O2) due to the synergistic effects of Rh and Pt. The catalytic mechanism of CA-RhPt NPs was found to decompose H2O2 to a hydroxyl radical (center dot OH), and then, the center dot OH oxidizes the TMB, generating a blue product. The excellent peroxidase-like CA-RhPt NPs were then applied to the colorimetric determination of cholesterol. The CA-RhPt NP-based colorimetry showed sensitive cholesterol detection in the range from 0.08 to 5.0 mM, with a detection limit of 25.7 mu M. The recoveries of cholesterol concentrations from the spiked human serum samples were 96.8% and 106%, which were comparable to those from the commercialized cholesterol detection kit. These results demonstrate the possibility of CA-RhPt NPs as alternatives for natural enzymes and applicability for sensitive cholesterol detection. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | American Chemical Society | - |
dc.title | Citric Acid-Functionalized Rhodium−Platinum Nanoparticles as Peroxidase Mimics for Determination of Cholesterol | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1021/acsanm.1c01457 | - |
dc.identifier.scopusid | 2-s2.0-85112511495 | - |
dc.identifier.wosid | 000692034900070 | - |
dc.identifier.bibliographicCitation | ACS Applied Nano Materials, v.4, no.8, pp 8282 - 8291 | - |
dc.citation.title | ACS Applied Nano Materials | - |
dc.citation.volume | 4 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 8282 | - |
dc.citation.endPage | 8291 | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | NANOCLUSTERS | - |
dc.subject.keywordPlus | FLUORESCENCE | - |
dc.subject.keywordPlus | PERFORMANCE | - |
dc.subject.keywordPlus | NANOSHEETS | - |
dc.subject.keywordPlus | BIOSENSOR | - |
dc.subject.keywordPlus | NANOZYME | - |
dc.subject.keywordPlus | ESTER | - |
dc.subject.keywordAuthor | bimetallic nanoparticles | - |
dc.subject.keywordAuthor | cholesterol | - |
dc.subject.keywordAuthor | colorimetry | - |
dc.subject.keywordAuthor | enzymatic assay | - |
dc.subject.keywordAuthor | nanozyme | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/acsanm.1c01457 | - |
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