ASpedia: a comprehensive encyclopedia of human alternative splicing
DC Field | Value | Language |
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dc.contributor.author | Hyung, Daejin | - |
dc.contributor.author | Kim, Jihyun | - |
dc.contributor.author | Cho, Soo Young | - |
dc.contributor.author | Park, Charny | - |
dc.date.accessioned | 2023-08-16T08:32:28Z | - |
dc.date.available | 2023-08-16T08:32:28Z | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.issn | 1362-4962 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/114376 | - |
dc.description.abstract | Alternative splicing confers the human genome complexity by increasing the diversity of expressed mRNAs. Hundreds or thousands of splicing regions have been identified through differential alternative splicing analysis of high-throughput datasets. However, it is hard to explain the functional impact of each splicing event. Protein domain formation and nonsense-mediated decay are considered the main functional features of splicing. However, other functional features such as miRNA target sites, phosphorylation sites and single-nucleotide variations are directly affected by alternative splicing and affect downstream function. Hence, we established ASpedia: A comprehensive database for human alternative splicing annotation, which encompasses a range of functions, from genomic annotation to isoform-specific function (ASpedia, http://combio.snu.ac.kr/aspedia). The database provides three features: (i) genomic annotation extracted from DNA, RNA and proteins; (ii) transcription and regulation elements analyzed from next-generation sequencing datasets; and (iii) isoform-specific functions collected from known and published datasets. The ASpedia web application includes three components: An annotation database, a retrieval system and a browser specialized in the identification of human alternative splicing events. The retrieval system supports multiple AS event searches resulting from high-throughput analysis and the AS browser comprises genome tracks. Thus, ASpedia facilitates the systemic annotation of the functional impacts of multiple AS events. © 2017 The Author(s). | - |
dc.publisher | Oxford University Press | - |
dc.title | ASpedia: a comprehensive encyclopedia of human alternative splicing | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1093/nar/gkx1014 | - |
dc.identifier.scopusid | 2-s2.0-85040930114 | - |
dc.identifier.wosid | 000419550700010 | - |
dc.identifier.bibliographicCitation | Nucleic Acids Research, v.46, no.D1, pp D58 - D63 | - |
dc.citation.title | Nucleic Acids Research | - |
dc.citation.volume | 46 | - |
dc.citation.number | D1 | - |
dc.citation.startPage | D58 | - |
dc.citation.endPage | D63 | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | HUMAN-TRANSCRIPTOME | - |
dc.subject.keywordPlus | DATABASE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ISOFORM | - |
dc.identifier.url | https://www.scopus.com/record/display.uri?eid=2-s2.0-85040930114&origin=inward&txGid=88905bfd3dad73cf9eb8eb59163a7b27#funding-details | - |
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