RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancer
DC Field | Value | Language |
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dc.contributor.author | Yang, Hanna | - |
dc.contributor.author | Hong, Dongwan | - |
dc.contributor.author | Cho, Soo Young | - |
dc.contributor.author | Park, Young Soo | - |
dc.contributor.author | Ko, Woo Ri | - |
dc.contributor.author | Kim, Ju Hee | - |
dc.contributor.author | Hur, Hoon | - |
dc.contributor.author | Lee, Jongkeun | - |
dc.contributor.author | Kim, Su-Jin | - |
dc.contributor.author | Kwon, Sun Young | - |
dc.contributor.author | Lee, Jae-Hyuk | - |
dc.contributor.author | Park, Do Youn | - |
dc.contributor.author | Song, Kyu Sang | - |
dc.contributor.author | Chang, Heekyung | - |
dc.contributor.author | Ryu, Min-Hee | - |
dc.contributor.author | Cho, Kye Soo | - |
dc.contributor.author | Kang, Jeong Won | - |
dc.contributor.author | Kook, Myeong-Cherl | - |
dc.contributor.author | Thiessen, Nina | - |
dc.contributor.author | He, An | - |
dc.contributor.author | Mungall, Andy | - |
dc.contributor.author | Han, Sang-Uk | - |
dc.contributor.author | Kim, Hark Kyun | - |
dc.date.accessioned | 2023-08-16T08:32:32Z | - |
dc.date.available | 2023-08-16T08:32:32Z | - |
dc.date.issued | 2018-12 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/114380 | - |
dc.description.abstract | We conducted an RNA sequencing study to identify novel gene fusions in 80 discovery dataset tumors collected from young patients with diffuse gastric cancer (DGC). Twenty-five in-frame fusions are associated with DGC, three of which (CLDN18-ARHGAP26, CTNND1-ARHGAP26, and ANXA2-MYO9A) are recurrent in 384 DGCs based on RT-PCR. All three fusions contain a RhoGAP domain in their 3’ partner genes. Patients with one of these three fusions have a significantly worse prognosis than those without. Ectopic expression of CLDN18-ARHGAP26 promotes the migration and invasion capacities of DGC cells. Parallel targeted RNA sequencing analysis additionally identifies TACC2-PPAPDC1A as a recurrent and poor prognostic in-frame fusion. Overall, PPAPDC1A fusions and in-frame fusions containing a RhoGAP domain clearly define the aggressive subset (7.5%) of DGCs, and their prognostic impact is greater than, and independent of, chromosomal instability and CDH1 mutations. Our study may provide novel genomic insights guiding future strategies for managing DGCs. © 2018, The Author(s). | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Nature Publishing Group | - |
dc.title | RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancer | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1038/s41467-018-06747-4 | - |
dc.identifier.scopusid | 2-s2.0-85055426187 | - |
dc.identifier.wosid | 000448264600004 | - |
dc.identifier.bibliographicCitation | Nature Communications, v.9, no.1, pp 1 - 13 | - |
dc.citation.title | Nature Communications | - |
dc.citation.volume | 9 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 13 | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | ROS1 REARRANGEMENT | - |
dc.subject.keywordPlus | SEQUENCING DATA | - |
dc.subject.keywordPlus | ARP2/3 COMPLEX | - |
dc.subject.keywordPlus | KINASE PATHWAY | - |
dc.subject.keywordPlus | GENE FUSIONS | - |
dc.subject.keywordPlus | MYOSIN IXA | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.subject.keywordPlus | CLONING | - |
dc.subject.keywordPlus | SMAD4 | - |
dc.identifier.url | https://www.nature.com/articles/s41467-018-06747-4 | - |
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