A brominated flame retardant 2,2',4,4' tetrabrominated diphenyl ether (BDE-47) leads to lipogenesis in the copepod Tigriopus japonicus
DC Field | Value | Language |
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dc.contributor.author | Lee, Min-Chul | - |
dc.contributor.author | Han, Jeonghoon | - |
dc.contributor.author | Lee, Seung-Hwi | - |
dc.contributor.author | Kim, Duck-Hyun | - |
dc.contributor.author | Kang, Hye-Min | - |
dc.contributor.author | Won, Eun-Ji | - |
dc.contributor.author | Hwang, Dae-Sik | - |
dc.contributor.author | Park, Jun Chul | - |
dc.contributor.author | Om, Ae-Son | - |
dc.contributor.author | Lee, Jae-Seong | - |
dc.date.accessioned | 2023-09-04T05:42:07Z | - |
dc.date.available | 2023-09-04T05:42:07Z | - |
dc.date.issued | 2016-09 | - |
dc.identifier.issn | 0166-445X | - |
dc.identifier.issn | 1879-1514 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/114856 | - |
dc.description.abstract | De novo lipogenesis (DNL) is a fatty acid synthesis process that requires several genes, including sterol regulatory element binding protein (SREBP), ATP-citrate lyase (ACLY), and acetyl-CoA carboxylase (ACC). DNL up-regulation is able to induce fat accumulation through an increase in fatty acids. To investigate the relationship between DNL up-regulation and the accumulation of fatty acids and lipid droplets in response to 2,2',4,4' tetrabrominated diphenyl ether (BDE-47), we examined DNL in the copepod Tigriopus japonicus. Transcription levels of DNL-related genes were increased after exposure to 2.5 mu g/L BDE-47 for 24 h. After exposure to 2.5 mu g/L BDE-47, palmitic acid was significantly increased (P<0.05) at days 1 and 4, along with upregulation of fatty acid synthesis-related genes (e.g., desaturases and elongases). However, docosahexaenoic acid and arachidonic acid were down-regulated at days 1 and 4, showing an antagonistic effect. Lipid droplet area significantly increased in Nile red staining analysis after 24 h of exposure to 2.5 mu g/L BDE-47 in T. japonicus, while DNL was down-regulated in response to 500 mu M salicylate (a lipogenesis inhibitor), indicating that BDE-47 exposure is closely associated with an increase in fatty acids in this copepod. This study provides a better understanding of the effects of BDE-47 on DNL in copepods. (C) 2016 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | A brominated flame retardant 2,2',4,4' tetrabrominated diphenyl ether (BDE-47) leads to lipogenesis in the copepod Tigriopus japonicus | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.aquatox.2016.07.002 | - |
dc.identifier.scopusid | 2-s2.0-84978696484 | - |
dc.identifier.wosid | 000382802100003 | - |
dc.identifier.bibliographicCitation | Aquatic Toxicology, v.178, pp 19 - 26 | - |
dc.citation.title | Aquatic Toxicology | - |
dc.citation.volume | 178 | - |
dc.citation.startPage | 19 | - |
dc.citation.endPage | 26 | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Marine & Freshwater Biology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Marine & Freshwater Biology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | FATTY-ACID DESATURASE | - |
dc.subject.keywordPlus | INTERTIDAL COPEPOD | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | POSTNATAL EXPOSURE | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | CONTAMINANTS | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordAuthor | Copepod | - |
dc.subject.keywordAuthor | Tigriopus japonicus | - |
dc.subject.keywordAuthor | BDE-47 | - |
dc.subject.keywordAuthor | De novo lipogenesis | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0166445X16301904?via%3Dihub | - |
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