Sutureless transplantation of in vivo priming human mesenchymal stem cell sheet promotes the therapeutic potential for cardiac repair
DC Field | Value | Language |
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dc.contributor.author | Choi, Andrew | - |
dc.contributor.author | Kim, Hyeok | - |
dc.contributor.author | Han, Hyeonseok | - |
dc.contributor.author | Park, Jae-Hyun | - |
dc.contributor.author | Kim, Jin-Ju | - |
dc.contributor.author | Sim, Woo-Sup | - |
dc.contributor.author | Lee, Seong Jin | - |
dc.contributor.author | Ban, Kiwon | - |
dc.contributor.author | Park, Hun-Jun | - |
dc.contributor.author | Kim, Dong Sung | - |
dc.date.accessioned | 2023-09-11T01:36:43Z | - |
dc.date.available | 2023-09-11T01:36:43Z | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 1758-5082 | - |
dc.identifier.issn | 1758-5090 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/115239 | - |
dc.description.abstract | The heart, contrary to its small size, vigorously pumps oxygen and nutrients to our entire body indeterminably; and thus, its dysfunction could be devastating. Until now, there ave been several major obstacles to applying a cardiac patch for the treatment for myocardial infarction, including poor integration and low engraftment rates, due to the highly-curved surface of the heart and its dynamic nature. Here, we demonstrate a novel way for a comprehensive cardiac repair achieved by the sutureless transplantation of a highly integrable in vivo priming bone marrow mesenchymal stem cell (BMSC) sheet based on the utilization of a highly aligned thermoresponsive nanofiber membrane. Moreover, we developed a BMSC sheet specialized for vascular regeneration through ‘in-vivo priming’ using human umbilical vein endothelial cells. A prolonged secretion of multiple angiogenic cytokines, such as vascular endothelial growth factor, angiopoietin-1, insulin-like growth factor-1, which was observed in vitro from the specialized BMSC sheet seemed to lead a significant improvement in the cardiac function, including intrinsic contractibility and remodeling. In this study, we provide strong evidence that in vivo priming of a human BMSC sheet develops the therapeutic potential for cardiac repair. © 2022 IOP Publishing Ltd. | - |
dc.format.extent | 16 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | IOP Publishing | - |
dc.title | Sutureless transplantation of in vivo priming human mesenchymal stem cell sheet promotes the therapeutic potential for cardiac repair | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1088/1758-5090/ac8dc9 | - |
dc.identifier.scopusid | 2-s2.0-85140856397 | - |
dc.identifier.wosid | 000874297800001 | - |
dc.identifier.bibliographicCitation | Biofabrication, v.15, no.1, pp 1 - 16 | - |
dc.citation.title | Biofabrication | - |
dc.citation.volume | 15 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 16 | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | VISCOELASTIC PROPERTIES | - |
dc.subject.keywordPlus | MYOCARDIUM | - |
dc.subject.keywordPlus | IMPLANTATION | - |
dc.subject.keywordPlus | NANOFIBERS | - |
dc.subject.keywordPlus | STRATEGIES | - |
dc.subject.keywordPlus | STIFFNESS | - |
dc.subject.keywordAuthor | cardiac repair | - |
dc.subject.keywordAuthor | in vivo priming | - |
dc.subject.keywordAuthor | nanofiber membrane | - |
dc.subject.keywordAuthor | poly (N-isopropylacrylamide) | - |
dc.subject.keywordAuthor | stem cell | - |
dc.subject.keywordAuthor | sutureless-transplantation | - |
dc.identifier.url | https://iopscience.iop.org/article/10.1088/1758-5090/ac8dc9 | - |
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