Development of a Simple, Precise, and Validated HPLC Method for the Anticancer Drug, Regorafenib: Application to Pharmacokinetics in Rats and Stability Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jung Suk | - |
dc.contributor.author | Cho, Jung Hyun | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.date.accessioned | 2023-12-11T08:00:20Z | - |
dc.date.available | 2023-12-11T08:00:20Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.issn | 1229-5949 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/116251 | - |
dc.description.abstract | The goal of this study was to establish a simple, precise, and validated high-performance liquid chromatography-ultraviolet (HPLC-UV) method to quantify the amount of regorafenib in rat plasma using revaprazan as an internal standard. The mobile phase composition was 0.1% aqueous trifluoroacetic acid solution and 0.1% trifluoroacetic acid in acetonitrile (50/50, v/v). The flow rate was 0.5 mL/min, and the eluent was monitored at 265 nm. The results showed that this novel chromatographic method achieved the criteria of the FDA validation guidelines and presented excellent linearity over 0.0488-50 mu g/mL (r(2) = 0.9999) concentration. Additionally, this method was validated for evaluating regorafenib stability in three different storage conditions and was effectively utilized to analyze the drug concentration in rat plasma after oral administration by calculating its pharmacokinetic parameters. Therefore, this HPLC method is appropriate for evaluating the pharmacokinetics of regorafenib in rats. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한화학회 | - |
dc.title | Development of a Simple, Precise, and Validated HPLC Method for the Anticancer Drug, Regorafenib: Application to Pharmacokinetics in Rats and Stability Study | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.1002/bkcs.12355 | - |
dc.identifier.scopusid | 2-s2.0-85115314319 | - |
dc.identifier.wosid | 000673394300001 | - |
dc.identifier.bibliographicCitation | Bulletin of the Korean Chemical Society, v.42, no.9, pp 1239 - 1244 | - |
dc.citation.title | Bulletin of the Korean Chemical Society | - |
dc.citation.volume | 42 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1239 | - |
dc.citation.endPage | 1244 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002754903 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | HUMAN PLASMA | - |
dc.subject.keywordPlus | UV METHOD | - |
dc.subject.keywordPlus | LIQUID-CHROMATOGRAPHY | - |
dc.subject.keywordPlus | BAY 73-4506 | - |
dc.subject.keywordPlus | QUANTIFICATION | - |
dc.subject.keywordPlus | METABOLITES | - |
dc.subject.keywordPlus | DAPTOMYCIN | - |
dc.subject.keywordAuthor | Regorafenib | - |
dc.subject.keywordAuthor | High-performance liquid chromatography-ultraviolet | - |
dc.subject.keywordAuthor | Validation | - |
dc.subject.keywordAuthor | Stability | - |
dc.subject.keywordAuthor | Pharmacokinetics | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.12355 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Korea+82-31-400-4269 sweetbrain@hanyang.ac.kr
COPYRIGHT © 2021 HANYANG UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.