Harnessing paper folding mechanism for reconfigurable DNA origami
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Myoungseok | - |
dc.contributor.author | Lee, Chanseok | - |
dc.contributor.author | Jeon, Kyounghwa | - |
dc.contributor.author | Lee, Jae Young | - |
dc.contributor.author | Kim, Young-Joo | - |
dc.contributor.author | Lee, Jae Gyung | - |
dc.contributor.author | Kim, Hyunsu | - |
dc.contributor.author | Cho, Maenghyo | - |
dc.contributor.author | Kim, Do-Nyun | - |
dc.date.accessioned | 2024-01-18T07:00:27Z | - |
dc.date.available | 2024-01-18T07:00:27Z | - |
dc.date.issued | 2023-07 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.issn | 1476-4687 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/117764 | - |
dc.description.abstract | The paper-folding mechanism has been widely adopted in building of reconfigurable macroscale systems because of its unique capabilities and advantages in programming variable shapes and stiffness into a structure1–5. However, it has barely been exploited in the construction of molecular-level systems owing to the lack of a suitable design principle, even though various dynamic structures based on DNA self-assembly6–9 have been developed10–23. Here we propose a method to harness the paper-folding mechanism to create reconfigurable DNA origami structures. The main idea is to build a reference, planar wireframe structure24 whose edges follow a crease pattern in paper folding so that it can be folded into various target shapes. We realized several paper-like folding and unfolding patterns using DNA strand displacement25 with high yield. Orthogonal folding, repeatable folding and unfolding, folding-based microRNA detection and fluorescence signal control were demonstrated. Stimuli-responsive folding and unfolding triggered by pH or light-source change were also possible. Moreover, by employing hierarchical assembly26 we could expand the design space and complexity of the paper-folding mechanism in a highly programmable manner. Because of its high programmability and scalability, we expect that the proposed paper-folding-based reconfiguration method will advance the development of complex molecular systems. © 2023, The Author(s), under exclusive licence to Springer Nature Limited. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Harnessing paper folding mechanism for reconfigurable DNA origami | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1038/s41586-023-06181-7 | - |
dc.identifier.scopusid | 2-s2.0-85163989686 | - |
dc.identifier.wosid | 001024763800017 | - |
dc.identifier.bibliographicCitation | Nature, v.619, no.7968, pp 78 - 86 | - |
dc.citation.title | Nature | - |
dc.citation.volume | 619 | - |
dc.citation.number | 7968 | - |
dc.citation.startPage | 78 | - |
dc.citation.endPage | 86 | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | NANOSTRUCTURES | - |
dc.subject.keywordPlus | ASSEMBLIES | - |
dc.subject.keywordPlus | DRIVEN | - |
dc.subject.keywordPlus | SHAPE | - |
dc.subject.keywordPlus | KINETICS | - |
dc.subject.keywordPlus | MACHINE | - |
dc.identifier.url | https://www.nature.com/articles/s41586-023-06181-7 | - |
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