The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation
DC Field | Value | Language |
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dc.contributor.author | Imai, Takashi | - |
dc.contributor.author | Lin, Juan | - |
dc.contributor.author | Kaya, Göksu Gökberk | - |
dc.contributor.author | Ju, Eunjin | - |
dc.contributor.author | Kondylis, Vangelis | - |
dc.contributor.author | Kelepouras, Konstantinos | - |
dc.contributor.author | Liccardi, Gianmaria | - |
dc.contributor.author | Kim, Chun | - |
dc.contributor.author | Pasparakis, Manolis | - |
dc.date.accessioned | 2024-06-11T07:00:36Z | - |
dc.date.available | 2024-06-11T07:00:36Z | - |
dc.date.issued | 2024-05 | - |
dc.identifier.issn | 1074-7613 | - |
dc.identifier.issn | 1097-4180 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/119297 | - |
dc.description.abstract | RIPK1 is a multi-functional kinase that regulates cell death and inflammation and has been implicated in the pathogenesis of inflammatory diseases. RIPK1 acts in a kinase-dependent and kinase-independent manner to promote or suppress apoptosis and necroptosis, but the underlying mechanisms remain poorly understood. Here, we show that a mutation (R588E) disrupting the RIPK1 death domain (DD) caused perinatal lethality induced by ZBP1-mediated necroptosis. Additionally, these mice developed postnatal inflammatory pathology, which was mediated by necroptosis-independent TNFR1, TRADD, and TRIF signaling, partially requiring RIPK3. Our biochemical mechanistic studies revealed that ZBP1- and TRIF-mediated activation of RIPK3 required RIPK1 kinase activity in wild-type cells but not in Ripk1R588E/R588E cells, suggesting that DD-dependent oligomerization of RIPK1 and its interaction with FADD determine the mechanisms of RIPK3 activation by ZBP1 and TRIF. Collectively, these findings revealed a critical physiological role of DD-dependent RIPK1 signaling that is important for the regulation of tissue homeostasis and inflammation. © 2024 The Author(s) | - |
dc.format.extent | 24 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Cell Press | - |
dc.title | The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.immuni.2024.04.016 | - |
dc.identifier.scopusid | 2-s2.0-85194561654 | - |
dc.identifier.bibliographicCitation | Immunity, pp 1 - 24 | - |
dc.citation.title | Immunity | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 24 | - |
dc.type.docType | Article in Press | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | caspase-8 | - |
dc.subject.keywordAuthor | FADD | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | necroptosis | - |
dc.subject.keywordAuthor | RIPK1 | - |
dc.subject.keywordAuthor | TNFR1 | - |
dc.subject.keywordAuthor | TRADD | - |
dc.subject.keywordAuthor | TRIF | - |
dc.subject.keywordAuthor | ZBP1 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1074761324002218?via%3Dihub | - |
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