Tailored synthesis of pH-responsive biodegradable microcapsules incorporating gelatin, alginate, and hyaluronic acid for effective-controlled release
DC Field | Value | Language |
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dc.contributor.author | Do, Uyen Thi | - |
dc.contributor.author | Nguyen, Quynh Thi | - |
dc.contributor.author | Kim, Jiwon | - |
dc.contributor.author | Luu, Quy Son | - |
dc.contributor.author | Park, Yeeun | - |
dc.contributor.author | Song, Minji | - |
dc.contributor.author | Yang, Seyoung | - |
dc.contributor.author | Choi, Jaehwa | - |
dc.contributor.author | Yun, Seokki | - |
dc.contributor.author | Kang, Dong-Ku | - |
dc.contributor.author | Lee, Youngbok | - |
dc.date.accessioned | 2024-06-19T08:00:26Z | - |
dc.date.available | 2024-06-19T08:00:26Z | - |
dc.date.issued | 2024-06 | - |
dc.identifier.issn | 0141-8130 | - |
dc.identifier.issn | 1879-0003 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/119528 | - |
dc.description.abstract | In response to escalating environmental concerns and the urgent need for sustainable drug delivery systems, this study introduces biodegradable pH -responsive microcapsules synthesized from a blend of gelatin, alginate, and hyaluronic acid. Employing the coacervation process, capsules were created with a spherical shape, multicore structure, and small sizes ranging from 10 to 20 mu m, which exhibit outstanding vitamin E encapsulation efficiency. With substantial incorporation of hyaluronic acid, a pH -responsive component, the resulting microcapsules displayed noteworthy swelling behavior, facilitating proficient core ingredient release at pH 5.5 and 7.4. Notably, these capsules can effectively deliver active substances to the dermal layer under specific skin conditions, revealing promising applications in topical medications and cosmetics. Furthermore, the readily biodegradable nature of the designed capsules was demonstrated through Biochemical Oxygen Demand (BOD) testing, with over 80 % of microcapsules being degraded by microorganisms after one week of incubation. This research contributes to the development of responsive microcapsules and aligns with broader environmental initiatives, offering a promising pathway to mitigate the impact of microplastics while advancing various applications. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Tailored synthesis of pH-responsive biodegradable microcapsules incorporating gelatin, alginate, and hyaluronic acid for effective-controlled release | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.ijbiomac.2024.132178 | - |
dc.identifier.scopusid | 2-s2.0-85193001988 | - |
dc.identifier.wosid | 001242099500001 | - |
dc.identifier.bibliographicCitation | International Journal of Biological Macromolecules, v.270, pp 1 - 11 | - |
dc.citation.title | International Journal of Biological Macromolecules | - |
dc.citation.volume | 270 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 11 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.subject.keywordPlus | VITAMIN-E | - |
dc.subject.keywordPlus | COMPLEX COACERVATION | - |
dc.subject.keywordPlus | SODIUM ALGINATE | - |
dc.subject.keywordPlus | PHYSICOCHEMICAL PROPERTIES | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | HYDROGELS | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | MICROENCAPSULATION | - |
dc.subject.keywordPlus | POLYSACCHARIDE | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordAuthor | Microcapsules | - |
dc.subject.keywordAuthor | Biodegradation | - |
dc.subject.keywordAuthor | Enterobacter xiangfangensis | - |
dc.subject.keywordAuthor | pH -responsive | - |
dc.subject.keywordAuthor | Controlled release | - |
dc.subject.keywordAuthor | Hyaluronic acid | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0141813024029830?via%3Dihub | - |
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