Rifamycin O, An Alternative Anti-Mycobacterium abscessus Agent
DC Field | Value | Language |
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dc.contributor.author | Bui Thi Bich Hanh | - |
dc.contributor.author | Park, June-Woo | - |
dc.contributor.author | Kim, Tae Ho | - |
dc.contributor.author | Kim, Jae-Sung | - |
dc.contributor.author | Yang, Chul-Su | - |
dc.contributor.author | Jang, Kiseok | - |
dc.contributor.author | Cui, Jinsheng | - |
dc.contributor.author | Oh, Dong-Chan | - |
dc.contributor.author | Jang, Jichan | - |
dc.date.accessioned | 2021-06-22T09:05:36Z | - |
dc.date.available | 2021-06-22T09:05:36Z | - |
dc.date.issued | 2020-04 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/1196 | - |
dc.description.abstract | Mycobacterium abscessus is the most difficult-to-treat nontuberculous mycobacteria because of its resistance to many antibiotics. In this study, we screened the Korea Chemical Bank library for a bioluminescent reporter assay to identify molecules capable of acting against M. abscessus. On application of the assay, rifamycin O showed excellent in vitro activity with a narrow range of the minimum inhibitory concentration required to inhibit the growth of 90% of the bacterium (MIC90 = 4.0-6.2 mu M); its in vivo efficacy in the zebrafish (Danio rerio) infection model was comparable to that of rifabutin at 25 mu M. Furthermore, rifamycin O did not show significant toxicity in cells and the zebrafish model. These results are the first in vivo indication that rifamycin O may be a drug candidate for treating M. abscessus infections. | - |
dc.format.extent | 15 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Rifamycin O, An Alternative Anti-Mycobacterium abscessus Agent | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/molecules25071597 | - |
dc.identifier.scopusid | 2-s2.0-85083041640 | - |
dc.identifier.wosid | 000531833400122 | - |
dc.identifier.bibliographicCitation | Molecules, v.25, no.7, pp 1 - 15 | - |
dc.citation.title | Molecules | - |
dc.citation.volume | 25 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 15 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | ZEBRAFISH | - |
dc.subject.keywordAuthor | rifamycin | - |
dc.subject.keywordAuthor | Mycobacterium abscessus | - |
dc.subject.keywordAuthor | zebrafish bacterial infection | - |
dc.subject.keywordAuthor | drug resistance | - |
dc.subject.keywordAuthor | non-tuberculous mycobacteria | - |
dc.identifier.url | https://www.mdpi.com/1420-3049/25/7/1597 | - |
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