Stem Cell Oriented Exosomes Regulate Cell Proliferation in Hepatoma Carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Karima, Gul | - |
dc.contributor.author | Shin, Kyusoon | - |
dc.contributor.author | Jeong, Jaemin | - |
dc.contributor.author | Choi, Dongho | - |
dc.contributor.author | Hwang, Kyung-Gyun | - |
dc.contributor.author | Hong, Jong Wook | - |
dc.date.accessioned | 2024-07-16T11:30:52Z | - |
dc.date.available | 2024-07-16T11:30:52Z | - |
dc.date.issued | 2023-04 | - |
dc.identifier.issn | 1226-8372 | - |
dc.identifier.issn | 1976-3816 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/119959 | - |
dc.description.abstract | Reprogrammed hepatic stem cells can generate a variety of extracellular vesicular particles including exosomes with similar therapeutic potential. However, their functional application in cancer therapy is restricted due to a poor understanding of their physical properties, anti-proliferative effects, and the underlying mechanism. Here, we explore reprogrammed stem cells that can release vesicular particles with physical properties of exosomes that can exert anti-proliferative effects by regulating cell proliferation-related genes. We obtain vesicular particles with properties of exosomes expressing CD81 and CD63 with the size distribution peak observed at 155 nm. We analyze that as compared to non-treated conditions, vesicular particles have reduced cell proliferation of Hep G2 by 93.6% after 72 h. Furthermore, we also identify that B-cell lymphoma 2 has been reduced by 89.64% and activation of caspase-3 has occurred in treated conditions via the mitochondrial pathway. Therefore, our results may highlight the potential of exosomes from hepatic stem cells to play a vital role in treating liver pathologies. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING | - |
dc.title | Stem Cell Oriented Exosomes Regulate Cell Proliferation in Hepatoma Carcinoma | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.1007/s12257-022-0238-y | - |
dc.identifier.scopusid | 2-s2.0-85159298229 | - |
dc.identifier.wosid | 000986494600004 | - |
dc.identifier.bibliographicCitation | BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, v.28, no.2, pp 263 - 273 | - |
dc.citation.title | BIOTECHNOLOGY AND BIOPROCESS ENGINEERING | - |
dc.citation.volume | 28 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 263 | - |
dc.citation.endPage | 273 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002959094 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MICRORNAS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | hepatocellular carcinoma | - |
dc.subject.keywordAuthor | stem cells | - |
dc.subject.keywordAuthor | exosome | - |
dc.subject.keywordAuthor | cell proliferation | - |
dc.subject.keywordAuthor | suppression | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s12257-022-0238-y | - |
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