Sustained release docetaxel-incorporated lipid nanoparticles with improved pharmacokinetics for oral and parenteral administration
DC Field | Value | Language |
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dc.contributor.author | Qureshi, Omer Salman | - |
dc.contributor.author | Kim, Hyung-Seo | - |
dc.contributor.author | Zeb, Alam | - |
dc.contributor.author | Choi, Jin-Seok | - |
dc.contributor.author | Kim, Hoo-Seong | - |
dc.contributor.author | Kwon, Jung-Eun | - |
dc.contributor.author | Kim, Myung-Sic | - |
dc.contributor.author | Kang, Jong-Ho | - |
dc.contributor.author | Ryou, Chongsuk | - |
dc.contributor.author | Park, Jeong-Sook | - |
dc.contributor.author | Kim, Jin-Ki | - |
dc.date.accessioned | 2021-06-22T15:41:51Z | - |
dc.date.available | 2021-06-22T15:41:51Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 0265-2048 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/12052 | - |
dc.description.abstract | The aim of this study was to develop docetaxel-incorporated lipid nanoparticles (DTX-NPs) to improve the pharmacokinetic behaviour of docetaxel (DTX) after oral and parenteral administration via sustained release. DTX-NPs were prepared by nanotemplate engineering technique with palmityl alcohol as a solid lipid and Tween-40/Span-40/Myrj S40 as a surfactants mixture. Spherical DTX-NPs below 100 nm were successfully prepared with a narrow particle size distribution, 96% of incorporation efficiency and 686 times increase in DTX solubility. DTX-NPs showed a sustained release over 24 h in phosphate-buffered saline and simulated gastric and intestinal fluids, while DTX-micelles released DTX completely within 12 h. The half-maximal inhibitory concentration (IC50) of DTX-NPs against human breast cancer MCF-7 cells was 1.9 times lower than that of DTX-micelles and DTX solution. DTX-NPs demonstrated 3.7- and 2.8-fold increase in the area under the plasma concentration-time curve compared with DTX-micelles after oral and parenteral administration, respectively. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Taylor & Francis | - |
dc.title | Sustained release docetaxel-incorporated lipid nanoparticles with improved pharmacokinetics for oral and parenteral administration | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ryou, Chongsuk | - |
dc.contributor.affiliatedAuthor | Kim, Jin-Ki | - |
dc.identifier.doi | 10.1080/02652048.2017.1337247 | - |
dc.identifier.scopusid | 2-s2.0-85020543130 | - |
dc.identifier.wosid | 000405503100003 | - |
dc.identifier.bibliographicCitation | Journal of Microencapsulation, v.34, no.3, pp.250 - 261 | - |
dc.relation.isPartOf | Journal of Microencapsulation | - |
dc.citation.title | Journal of Microencapsulation | - |
dc.citation.volume | 34 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 250 | - |
dc.citation.endPage | 261 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | CONTROLLED DRUG-DELIVERY | - |
dc.subject.keywordPlus | IN-VIVO EVALUATION | - |
dc.subject.keywordPlus | ANTICANCER DRUGS | - |
dc.subject.keywordPlus | TUMOR MICROENVIRONMENT | - |
dc.subject.keywordPlus | VITRO | - |
dc.subject.keywordPlus | CYTOTOXICITY | - |
dc.subject.keywordPlus | NANOCARRIERS | - |
dc.subject.keywordPlus | CARRIERS | - |
dc.subject.keywordPlus | SYSTEMS | - |
dc.subject.keywordPlus | SLN | - |
dc.subject.keywordAuthor | Lipid nanoparticles | - |
dc.subject.keywordAuthor | docetaxel | - |
dc.subject.keywordAuthor | sustained release | - |
dc.subject.keywordAuthor | pharmacokinetics | - |
dc.subject.keywordAuthor | bioavailability | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/02652048.2017.1337247 | - |
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