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Safety evaluation of a forward-viewing intravascular transducer for Sonothrombolysis: An in vitro and ex vivo study
- Authors
- Goel, Leela; Wu, Huaiyu; Zhang, Bohua; Kim, Jinwook; Dayton, Paul A.; Xu, Zhen; Jiang, Xiaoning
- Issue Date
- Nov-2021
- Publisher
- Elsevier BV
- Keywords
- Intravascular sonothrombolysis; Microbubbles; Nanodroplets; Retracted clots; Safety; Tissue plasminogen activator; Ultrasound-assisted thrombolysis
- Citation
- Ultrasound in Medicine and Biology, v.47, no.11, pp 3231 - 3239
- Pages
- 9
- Indexed
- SCIE
SCOPUS
- Journal Title
- Ultrasound in Medicine and Biology
- Volume
- 47
- Number
- 11
- Start Page
- 3231
- End Page
- 3239
- ISSN
- 0301-5629
1879-291X
- Abstract
- Recent in vitro work has revealed that a forward-viewing intravascular (FVI) transducer has sonothrombolysis applications. However, the safety of this device has yet to be evaluated. In this study, we evaluated the safety of this device in terms of tissue heating, vessel damage and particle debris size during sonothrombolysis using microbubbles or nanodroplets with tissue plasminogen activator, in both retracted and unretracted blood clots. The in vitro and ex vivo sonothrombolysis tests using FVI transducers revealed a temperature rise of less than 1°C, no vessel damage as assessed by histology and no downstream clot particles >500 µm. These in vitro and ex vivo results indicate that the FVI transducer poses minimal risk for sonothrombolysis applications and should be further evaluated in animal models. © 2021 World Federation for Ultrasound in Medicine & Biology
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