Characterization of in vitro metabolites of methylenedioxypyrovalerone (MDPV): An N-oxide metabolite formation mediated by flavin monooxygenase
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, In Sook | - |
dc.contributor.author | Rehman, Shaheed Ur | - |
dc.contributor.author | Choi, Min Sun | - |
dc.contributor.author | Jang, Moonhee | - |
dc.contributor.author | Yang, Wonkyung | - |
dc.contributor.author | Kim, Eunmi | - |
dc.contributor.author | Yoo, Hye Hyun | - |
dc.date.accessioned | 2021-06-22T15:44:42Z | - |
dc.date.available | 2021-06-22T15:44:42Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2016-11 | - |
dc.identifier.issn | 0731-7085 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/12195 | - |
dc.description.abstract | Methylenedioxypyrovalerone (MDPV) has emerged in recent years as a-recreational substance with psychostimulant properties. In this study, in vitro metabolites of MDPV were characterized based on liquid chromatography/quadrupole-time-of-flight mass spectrometry(LC/QTOF MS). MDPV was incubated with human liver microsomes, human recombinant cDNA-expressed cytochrome P450 enzymes and flavin monooxygenase (FMO). MDPV was metabolized to yield eight metabolites (M1-M8)with major metabolic reactions such as demethylenation and oxidation. Among them, M6 was assigned as an N-oxide metabolite. FMO was found to be a principal enzyme responsible for the formation of M6; FMO1 and FMO3 were the main enzymes involved in N-oxidation of MDPV. (C) 2016 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier BV | - |
dc.title | Characterization of in vitro metabolites of methylenedioxypyrovalerone (MDPV): An N-oxide metabolite formation mediated by flavin monooxygenase | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Hye Hyun | - |
dc.identifier.doi | 10.1016/j.jpba.2016.08.025 | - |
dc.identifier.scopusid | 2-s2.0-84984843541 | - |
dc.identifier.wosid | 000387628400022 | - |
dc.identifier.bibliographicCitation | Journal of Pharmaceutical and Biomedical Analysis, v.131, pp.160 - 166 | - |
dc.relation.isPartOf | Journal of Pharmaceutical and Biomedical Analysis | - |
dc.citation.title | Journal of Pharmaceutical and Biomedical Analysis | - |
dc.citation.volume | 131 | - |
dc.citation.startPage | 160 | - |
dc.citation.endPage | 166 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | RESOLUTION MASS-SPECTROMETRY | - |
dc.subject.keywordPlus | 3,4-METHYLENEDIOXYPYROVALERONE MDPV | - |
dc.subject.keywordPlus | BATH SALTS | - |
dc.subject.keywordPlus | DRUG-METABOLISM | - |
dc.subject.keywordPlus | PHARMACOLOGY | - |
dc.subject.keywordPlus | TRANSPORTER | - |
dc.subject.keywordPlus | CATHINONES | - |
dc.subject.keywordPlus | TOXICOLOGY | - |
dc.subject.keywordPlus | CHEMISTRY | - |
dc.subject.keywordPlus | URINE | - |
dc.subject.keywordAuthor | Methylenedioxypyrovalerone | - |
dc.subject.keywordAuthor | Metabolite | - |
dc.subject.keywordAuthor | N-oxide | - |
dc.subject.keywordAuthor | FMO | - |
dc.subject.keywordAuthor | Human liver microsomes | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0731708516304708?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Korea+82-31-400-4269 sweetbrain@hanyang.ac.kr
COPYRIGHT © 2021 HANYANG UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.