Enhanced acute anti-inflammatory effects of CORM-2-loaded nanoparticles via sustained carbon monoxide delivery
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Qureshi, Omer Salman | - |
dc.contributor.author | Zeb, Alam | - |
dc.contributor.author | Akram, Muhammad | - |
dc.contributor.author | Kim, Myung-Sic | - |
dc.contributor.author | Kang, Jong-Ho | - |
dc.contributor.author | Kim, Hoo-Seong | - |
dc.contributor.author | Majid, Arshad | - |
dc.contributor.author | Han, Inbo | - |
dc.contributor.author | Chang, Sun-Young | - |
dc.contributor.author | Bae, Ok-Nam | - |
dc.contributor.author | Kim, Jin-Ki | - |
dc.date.accessioned | 2021-06-22T16:01:53Z | - |
dc.date.available | 2021-06-22T16:01:53Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2016-11 | - |
dc.identifier.issn | 0939-6411 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/12558 | - |
dc.description.abstract | The aim of this study was to enhance the anti-inflammatory effects of carbon monoxide (CO) via sustained release of CO from carbon monoxide-releasing molecule-2-loaded lipid nanoparticles (CORM-2-NPs). CORM-2-NPs were prepared by hot high pressure homogenization method using trilaurin as a solid lipid core and Tween 20/Span 20/Myrj S40 as surfactant mixture. The physicochemical properties of CORM-2-NPs were characterized and CO release from CORM-2-NPs was assessed by myoglobin assay. In vitro anti-inflammatory effects were evaluated by nitric oxide assay in lipopolysaccharide-stimulated RAW 264.7 macrophages. In vivo anti-inflammatory activity was investigated by measuring paw volumes and histological examination in carrageenan-induced rat paw edema. Spherical CORM-2-NPs were around 100 nm with narrow particle size distribution. The sustained CO release from CORM-2-NPs was observed and the half-life of CO release increased up to 10 times compared with CORM-2 solution. CORM-2-NPs showed enhanced in vitro anti-inflammatory effects by inhibition of nitric oxide production. Edema volume in rat paw was significantly reduced after treatment with CORM-2-NPs. Taken together, CORM-2-NPs have a great potential for CO therapeutics against inflammation via sustained release of CO. (C) 2016 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.title | Enhanced acute anti-inflammatory effects of CORM-2-loaded nanoparticles via sustained carbon monoxide delivery | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bae, Ok-Nam | - |
dc.contributor.affiliatedAuthor | Kim, Jin-Ki | - |
dc.identifier.doi | 10.1016/j.ejpb.2016.09.008 | - |
dc.identifier.scopusid | 2-s2.0-84987891996 | - |
dc.identifier.wosid | 000388052600020 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v.108, pp.187 - 195 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | - |
dc.citation.title | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | - |
dc.citation.volume | 108 | - |
dc.citation.startPage | 187 | - |
dc.citation.endPage | 195 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | SOLID LIPID NANOPARTICLES | - |
dc.subject.keywordPlus | MOLECULES CO-RMS | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | SLN | - |
dc.subject.keywordPlus | CARRIERS | - |
dc.subject.keywordPlus | ROUTES | - |
dc.subject.keywordPlus | ASSAY | - |
dc.subject.keywordPlus | NLC | - |
dc.subject.keywordAuthor | Carbon monoxide | - |
dc.subject.keywordAuthor | CORM-2 | - |
dc.subject.keywordAuthor | Lipid nanoparticles | - |
dc.subject.keywordAuthor | Sustained release | - |
dc.subject.keywordAuthor | Anti-inflammatory effect | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0939641116305525?via%3Dihub | - |
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