A newly synthesized macakurzin C-derivative attenuates acute and chronic skin inflammation: The Nrf2/heme oxygenase signaling as a potential target
DC Field | Value | Language |
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dc.contributor.author | Akram, Muhammad | - |
dc.contributor.author | Shin, Iljin | - |
dc.contributor.author | Kim, Kyeong-A | - |
dc.contributor.author | Noh, Dabi | - |
dc.contributor.author | Baek, Seung-Hoon | - |
dc.contributor.author | Chang, Sun-Young | - |
dc.contributor.author | Kim, Hyoungsu | - |
dc.contributor.author | Bae, Ok-Nam | - |
dc.date.accessioned | 2021-06-22T16:21:33Z | - |
dc.date.available | 2021-06-22T16:21:33Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2016-09 | - |
dc.identifier.issn | 0041-008X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/13040 | - |
dc.description.abstract | Impaired immune responses in skin play a pivotal role in the development and progression of chemical-associated inflammatory skin disorders. In this study, we synthesized new flavonoid derivatives from macakurzin C, and identified in vitro and in vivo efficacy of a potent anti-inflammatory flavonoid, Compound 14 (CPD 14), with its underlying mechanisms. In lipopolysaccharide (LPS)-stimulated murine macrophages and IFN-gamma/TNF-alpha-stimulated human keratinocytes, CPD 14 significantly inhibited the release of inflammatory mediators including nitric oxide (NO), prostaglandins, and cytokines (IC50 for NO inhibition in macrophages: 4.61 mu M). Attenuated NF-kappa B signaling and activated Nrf2/HO-1 pathway were responsible for the anti-inflammatory effects of CPD 14. The in vivo relevance was examined in phorbol 12-myristate 13-acetate (TPA)-induced acute skin inflammation and oxazolone-induced atopic dermatitis models. Topically applied CPD 14 significantly protected both irritation- and sensitization-associated skin inflammation by suppressing the expression of inflammatory mediators. In summary, we demonstrated that a newly synthesized flavonoid, CPD 14, has potent inhibitory effects on skin inflammation, suggesting it is a potential therapeutic candidate to treat skin disorders associated with excessive inflammation. (C) 2016 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | A newly synthesized macakurzin C-derivative attenuates acute and chronic skin inflammation: The Nrf2/heme oxygenase signaling as a potential target | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bae, Ok-Nam | - |
dc.identifier.doi | 10.1016/j.taap.2016.07.013 | - |
dc.identifier.scopusid | 2-s2.0-84979581603 | - |
dc.identifier.wosid | 000382417400006 | - |
dc.identifier.bibliographicCitation | TOXICOLOGY AND APPLIED PHARMACOLOGY, v.307, pp.62 - 71 | - |
dc.relation.isPartOf | TOXICOLOGY AND APPLIED PHARMACOLOGY | - |
dc.citation.title | TOXICOLOGY AND APPLIED PHARMACOLOGY | - |
dc.citation.volume | 307 | - |
dc.citation.startPage | 62 | - |
dc.citation.endPage | 71 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTORS NRF2 | - |
dc.subject.keywordPlus | ATOPIC-DERMATITIS | - |
dc.subject.keywordPlus | ANTIINFLAMMATORY ACTIVITY | - |
dc.subject.keywordPlus | BIOLOGICAL EVALUATION | - |
dc.subject.keywordPlus | CONTACT-DERMATITIS | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | OXAZOLONE | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordAuthor | Synthetic flavonoid | - |
dc.subject.keywordAuthor | Anti-inflammatory activity | - |
dc.subject.keywordAuthor | TPA-induced acute inflammation | - |
dc.subject.keywordAuthor | Oxazolone-induced atopic dermatitis | - |
dc.identifier.url | https://linkinghub.elsevier.com/retrieve/pii/S0041008X16301971 | - |
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