Self-healing Elastin-bioglass Hydrogels
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zeng,Qiongyu | - |
dc.contributor.author | Desai,Malav S. | - |
dc.contributor.author | Jin, Hyo-Eon | - |
dc.contributor.author | Lee, Ju Hun | - |
dc.contributor.author | Chang, Jiang | - |
dc.contributor.author | Lee,Seung-Wuk | - |
dc.date.accessioned | 2021-06-22T16:23:13Z | - |
dc.date.available | 2021-06-22T16:23:13Z | - |
dc.date.created | 2021-02-18 | - |
dc.date.issued | 2016-08 | - |
dc.identifier.issn | 1525-7797 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/13110 | - |
dc.description.abstract | Tailorable hydrogels that are mechanically robust, injectable, and self-healable, are useful for many biomedical applications including tissue repair and drug delivery. Here we use biological and chemical engineering approaches to develop a novel in situ forming organic/inorganic composite hydrogel with dynamic aldimine crosslinks using elastin-like polypeptides (ELP) and bioglass (BG). The resulting ELP/BG biocomposites exhibit tunable gelling behavior and mechanical characteristics in a composition and concentration dependent manner. We also demonstrate self-healing in the ELP/BG hydrogels by successfully reattaching severed pieces as well as through rheology. In addition, we show the strength of genetic engineering to easily customize ELP by fusing cell-stimulating “RGD” peptide motifs. We showed that the resulting composite materials are cytocompatible as they support the cellular growth and attachment. Our robust in situ forming ELP/BG composite hydrogels will be useful as injectable scaffolds for delivering cell and drug molecules to promote soft tissue regeneration in the future. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | American Chemical Society | - |
dc.title | Self-healing Elastin-bioglass Hydrogels | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Ju Hun | - |
dc.identifier.doi | 10.1021/acs.biomac.6b00621 | - |
dc.identifier.scopusid | 2-s2.0-84981234342 | - |
dc.identifier.wosid | 000381231600012 | - |
dc.identifier.bibliographicCitation | Biomacromolecules, v.17, no.8, pp.2619 - 2625 | - |
dc.relation.isPartOf | Biomacromolecules | - |
dc.citation.title | Biomacromolecules | - |
dc.citation.volume | 17 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 2619 | - |
dc.citation.endPage | 2625 | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.subject.keywordPlus | Cell engineering | - |
dc.subject.keywordPlus | Composite materials | - |
dc.subject.keywordPlus | Elastin | - |
dc.subject.keywordPlus | Genetic engineering | - |
dc.subject.keywordPlus | Glycoproteins | - |
dc.subject.keywordPlus | Mechanical properties | - |
dc.subject.keywordPlus | Medical applications | - |
dc.subject.keywordPlus | Polypeptides | - |
dc.subject.keywordPlus | Scaffolds (biology) | - |
dc.subject.keywordPlus | Tissue | - |
dc.subject.keywordPlus | Tissue regeneration | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/acs.biomac.6b00621 | - |
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