RETRACTED: The Aminopyridinol Derivative BJ-1201 Protects Murine Hippocampal Cells against Glutamate-Induced Neurotoxicity via Heme Oxygenase-1 (Retracted Article. See vol 21, Art no 1463, 2016)
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Dong-Sung | - |
dc.contributor.author | Nam, Tae-Gyu | - |
dc.contributor.author | Jeong, Byeong-Seon | - |
dc.contributor.author | Jeong, Gil-Saeng | - |
dc.date.accessioned | 2021-06-22T17:01:30Z | - |
dc.date.available | 2021-06-22T17:01:30Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2016-05 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/14023 | - |
dc.description.abstract | Glutamate is the major excitatory neurotransmitter in the brain. It can cause neuronal cell damage in the context of oxidative stress. BJ-1201 is a derivative of the compound aminopyridinol, which is known for its antioxidant activity. In this study, we examined the effect of BJ-1201, a 6-(diphenylamino)-2,4,5-trimethylpyridin-3-ol compound, on neuroprotection in HT22 cells. Our data showed that BJ-1201 can protect HT22 cells against glutamate-induced cell cytotoxicity. In addition, BJ-1201 upregulated heme oxygenase-1 (HO-1) to levels comparable to those of the CoPP-treated group. BJ-1201 treatment induced phosphorylation of JNK, but not p38-MAPK or ERK. It also increased the signal in the reporter assay based on beta-galactosidase activity driven by the nuclear transcription factor erythroid-2 related factor 2 (Nrf2) promoter harboring antioxidant response elements (AREs) and induced the translocation of Nrf2. These results demonstrate that BJ-1201 may be a good therapeutic platform against neurodegenerative diseases induced by oxidative stress. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.title | RETRACTED: The Aminopyridinol Derivative BJ-1201 Protects Murine Hippocampal Cells against Glutamate-Induced Neurotoxicity via Heme Oxygenase-1 (Retracted Article. See vol 21, Art no 1463, 2016) | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Nam, Tae-Gyu | - |
dc.identifier.doi | 10.3390/molecules21050594 | - |
dc.identifier.scopusid | 2-s2.0-84973596725 | - |
dc.identifier.wosid | 000380241600058 | - |
dc.identifier.bibliographicCitation | MOLECULES, v.21, no.5, pp.1 - 11 | - |
dc.relation.isPartOf | MOLECULES | - |
dc.citation.title | MOLECULES | - |
dc.citation.volume | 21 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Retracted Publication | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | NEUROPROTECTIVE ACTIVITY | - |
dc.subject.keywordPlus | THERAPEUTIC TARGET | - |
dc.subject.keywordPlus | NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | HT22 NEURONS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | NEUROINFLAMMATION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | EXCITOTOXICITY | - |
dc.subject.keywordAuthor | aminopyridinol compound BJ-1201 | - |
dc.subject.keywordAuthor | neuroprotection | - |
dc.subject.keywordAuthor | aminopyridinol HT22 | - |
dc.subject.keywordAuthor | heme oxygenase-1 | - |
dc.subject.keywordAuthor | nuclear transcription factor erythroid-2 related factor 2 | - |
dc.identifier.url | https://www.mdpi.com/1420-3049/21/5/594 | - |
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