Treatment of bleomycin-induced pulmonary fibrosis by inhaled tacrolimus-loaded chitosan-coated poly(lactic-co-glycolic acid) nanoparticles
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Changkyu | - |
dc.contributor.author | Seo, Jisoo | - |
dc.contributor.author | Hwang, Ha Shin | - |
dc.contributor.author | Thao, Le Quang | - |
dc.contributor.author | Lee, Seunghyun | - |
dc.contributor.author | Lee, Eun Seong | - |
dc.contributor.author | Lee, Eun Hee | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.contributor.author | Youn, Yu Seok | - |
dc.date.accessioned | 2021-06-22T17:05:02Z | - |
dc.date.available | 2021-06-22T17:05:02Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2016-03 | - |
dc.identifier.issn | 0753-3322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/14183 | - |
dc.description.abstract | Pulmonary fibrosis is a chronic lung disease characterized by inflammation and collagen deposition, with an estimated mortality rate exceeding 70%. Here, we evaluated the therapeutic effectiveness of inhaled tacrolimus-loaded chitosan-coated poly(lactic-co-glycolic acid) nanoparticles (chitosan TAC PLGA-NPs) in a bleomycin-induced pulmonary fibrosis mouse model. Chitosan TAC PLGA-NPs were fabricated using an o/w emulsification diffusion method, and uncoated TAC PLGA-NPs and chitosan TAC PLGA-NPs were spherical with approximate diameters of 320 and 441 nm, respectively. The zeta potential of chitosan TAC PLGA-NPs (+ 13.6 mV) was increased significantly by chitosan-coating versus uncoated TAC PLGA-NPs (similar to 28.3 mV). The incorporation efficiency of tacrolimus was 37.7%, and the tacrolimus was gradually released until about 5 day. Direct inhalation of chitosan TAC PLGA-NPs (TAC 180 mg/mouse) twice a week produced marked anti-fibrotic efficacy in mice with bleomycin-induced pulmonary fibrosis, which was much better than the efficacy resulting from daily oral administration (TAC 300 mg/mouse) on the basis of hematoxylin/eosin and Masson's trichrome staining assessments. Imaging of lung deposition showed that chitosan TAC PLGA-NPs were located well in the lungs and gradually faded over 96 h. The pulmonary delivery of tacrolimus could be therapeutically efficacious for treating pulmonary fibrosis. TAC-loaded PLGA nanoparticles should be considered to be an efficient sustained-release type inhalation system that reduces administration frequency and relevant side effects. (C) 2016 Elsevier Masson SAS. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | - |
dc.title | Treatment of bleomycin-induced pulmonary fibrosis by inhaled tacrolimus-loaded chitosan-coated poly(lactic-co-glycolic acid) nanoparticles | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Han-Gon | - |
dc.identifier.doi | 10.1016/j.biopha.2016.01.027 | - |
dc.identifier.scopusid | 2-s2.0-84958622047 | - |
dc.identifier.wosid | 000370535300029 | - |
dc.identifier.bibliographicCitation | BIOMEDICINE & PHARMACOTHERAPY, v.78, pp.226 - 233 | - |
dc.relation.isPartOf | BIOMEDICINE & PHARMACOTHERAPY | - |
dc.citation.title | BIOMEDICINE & PHARMACOTHERAPY | - |
dc.citation.volume | 78 | - |
dc.citation.startPage | 226 | - |
dc.citation.endPage | 233 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | GROWTH-FACTOR-BETA | - |
dc.subject.keywordPlus | PLGA MICROPARTICLES | - |
dc.subject.keywordPlus | LUNG COLLAGEN | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | MUCOADHESION | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | DRUG | - |
dc.subject.keywordAuthor | Tacrolimus | - |
dc.subject.keywordAuthor | PLGA nanoparticle | - |
dc.subject.keywordAuthor | Chitosan | - |
dc.subject.keywordAuthor | Pulmonary fibrosis | - |
dc.subject.keywordAuthor | Inhalation | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0753332215302389?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Korea+82-31-400-4269 sweetbrain@hanyang.ac.kr
COPYRIGHT © 2021 HANYANG UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.