Therapeutic advantage of inhaled tacrolimus-bound albumin nanoparticles in a bleomycin-induced pulmonary fibrosis mouse model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, Jisoo | - |
dc.contributor.author | Lee, Changkyu | - |
dc.contributor.author | Hwang, Ha Shin | - |
dc.contributor.author | Kim, Bomi | - |
dc.contributor.author | Le Quang Thao | - |
dc.contributor.author | Lee, Eun Seong | - |
dc.contributor.author | Oh, Kyung Taek | - |
dc.contributor.author | Lim, Jong -Lae | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.contributor.author | Youn, Yu Seok | - |
dc.date.accessioned | 2021-06-22T17:22:35Z | - |
dc.date.available | 2021-06-22T17:22:35Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2016-02 | - |
dc.identifier.issn | 1094-5539 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/14555 | - |
dc.description.abstract | Tacrolimus (Tac) is an immunosuppressant that inhibits translocation of nuclear factor of activated T cells and has therapeutic potential for pulmonary fibrosis. Here, we investigated the therapeutic efficacy of a sustained-release type inhaled Tac formulation for treating bleomycin-induced pulmonary fibrosis. Inhalation has many meaningful advantages over injections, such as improved patient compliance, safety, and therapeutic effect. To this end, we fabricated inhalable albumin nanoparticles with bound Tac (Tac Alb-NPs) at a daily therapeutic dose (60) mu g/mouse) using a high-pressure homogenizer via nano particle albumin-bound technology. The Tac Alb-NPs were spherical, similar to 182.1 +/- 28.5 nm in size, with a zeta potential of -34.5 +/- 03 mV, and the Tac incorporation efficiency was as high as similar to 85.3%. The bound tacrolimus was released gradually from Tac Alb-NPs for similar to 24 h, which was sufficient time for pulmonary delivery. Most of all, the inhaled Tac Alb-NPs displayed remarkable anti-fibrotic efficacy in mice with bleomycin-induced pulmonary fibrosis, which was much better than the efficacy resulting from intraperitoneal administration of Tac (60 mu g/mouse) based on histopathological results (hematoxylin and eosin and Masson's trichrome staining). Furthermore, the inhaled Cy5.5-labelled Tac Alb-NPs were visualized throughout the lungs of mice for similar to 48 h, indicating direct exposure to fibrotic tissues in lung lesions. In conclusion, Tac Alb-NPs offer great potential as an inhalation delivery formulation for treating pulmonary fibrosis. Additionally, these NPs would be particularly useful as an effective and safe prototype for delivering practically insoluble therapeutic agents into the lungs. (C) 2016 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | - |
dc.title | Therapeutic advantage of inhaled tacrolimus-bound albumin nanoparticles in a bleomycin-induced pulmonary fibrosis mouse model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Han-Gon | - |
dc.identifier.doi | 10.1016/j.pupt.2016.01.001 | - |
dc.identifier.scopusid | 2-s2.0-84957608493 | - |
dc.identifier.wosid | 000371100300007 | - |
dc.identifier.bibliographicCitation | PULMONARY PHARMACOLOGY & THERAPEUTICS, v.36, pp.53 - 61 | - |
dc.relation.isPartOf | PULMONARY PHARMACOLOGY & THERAPEUTICS | - |
dc.citation.title | PULMONARY PHARMACOLOGY & THERAPEUTICS | - |
dc.citation.volume | 36 | - |
dc.citation.startPage | 53 | - |
dc.citation.endPage | 61 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | METASTATIC LUNG-CANCER | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | PLGA MICROPARTICLES | - |
dc.subject.keywordPlus | INHALATION SYSTEM | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | STRATEGIES | - |
dc.subject.keywordPlus | EXENDIN-4 | - |
dc.subject.keywordPlus | COLLAGEN | - |
dc.subject.keywordAuthor | Tacrolimus | - |
dc.subject.keywordAuthor | Pulmonary fibrosis | - |
dc.subject.keywordAuthor | Albumin nanoparticles | - |
dc.subject.keywordAuthor | Inhalation | - |
dc.subject.keywordAuthor | Bleomycin-induced fibrosis model | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1094553916300013?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Korea+82-31-400-4269 sweetbrain@hanyang.ac.kr
COPYRIGHT © 2021 HANYANG UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.