Aspirin induces IL-4 production: augmented IL-4 production in aspirin-exacerbated respiratory disease
DC Field | Value | Language |
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dc.contributor.author | Kong, Su-Kang | - |
dc.contributor.author | Kim, Byung Soo | - |
dc.contributor.author | Uhm, Tae Gi | - |
dc.contributor.author | Chang, Hun Soo | - |
dc.contributor.author | Park, Jong Sook | - |
dc.contributor.author | Park, Sung Woo | - |
dc.contributor.author | Park, Choon-Sik | - |
dc.contributor.author | Chung, Il Yup | - |
dc.date.accessioned | 2021-06-22T17:24:37Z | - |
dc.date.available | 2021-06-22T17:24:37Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2016-01 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/14649 | - |
dc.description.abstract | Aspirin hypersensitivity is a hallmark of aspirin-exacerbated respiratory disease (AERD), a clinical syndrome characterized by the severe inflammation of the respiratory tract after ingestion of cyclooxygenase-1 inhibitors. We investigated the capacity of aspirin to induce interleukin-4 (IL-4) production in inflammatory cells relevant to AERD pathogenesis and examined the associated biochemical and molecular pathways. We also compared IL-4 production in peripheral blood mononuclear cells (PBMCs) from patients with AERD vs aspirin-tolerant asthma (ATA) upon exposure to aspirin. Aspirin induced IL-4 expression and activated the IL-4 promoter in a report assay. The capacity of aspirin to induce IL-4 expression correlated with its activity to activate mitogen-activated protein kinases, to form DNA-protein complexes on P elements in the IL-4 promoter and to synthesize nuclear factor of activated T cells, critical transcription factors for IL-4 transcription. Of clinical importance, aspirin upregulated IL-4 production twice as much in PBMCs from patients with AERD compared with PBMCs from patients with ATA. Our results suggest that IL-4 is an inflammatory component mediating intolerance reactions to aspirin, and thus is crucial for AERD pathogenesis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 생화학분자생물학회 | - |
dc.title | Aspirin induces IL-4 production: augmented IL-4 production in aspirin-exacerbated respiratory disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chung, Il Yup | - |
dc.identifier.doi | 10.1038/emm.2015.96 | - |
dc.identifier.scopusid | 2-s2.0-85007243630 | - |
dc.identifier.wosid | 000369163200002 | - |
dc.identifier.bibliographicCitation | Experimental and Molecular Medicine, v.48, pp.1 - 10 | - |
dc.relation.isPartOf | Experimental and Molecular Medicine | - |
dc.citation.title | Experimental and Molecular Medicine | - |
dc.citation.volume | 48 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 10 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002076499 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | INFLAMMATORY CELL-POPULATIONS | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | LEUKOTRIENE C-4 SYNTHASE | - |
dc.subject.keywordPlus | HUMAN MAST-CELLS | - |
dc.subject.keywordPlus | HUMAN T-CELLS | - |
dc.subject.keywordPlus | CYSTEINYL-LEUKOTRIENES | - |
dc.subject.keywordPlus | SENSITIVE ASTHMATICS | - |
dc.subject.keywordPlus | SALICYLATES INHIBIT | - |
dc.subject.keywordPlus | SODIUM-SALICYLATE | - |
dc.identifier.url | https://www.nature.com/articles/emm201596 | - |
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