RNA interference-mediated suppression of TNF-α converting enzyme as an alternative anti-TNF-α therapy for rheumatoid arthritis
DC Field | Value | Language |
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dc.contributor.author | Song, Yoonsung | - |
dc.contributor.author | Jo, Sungsin | - |
dc.contributor.author | Chung, Jee Young | - |
dc.contributor.author | Oh, Younseo | - |
dc.contributor.author | Yoon, Subin | - |
dc.contributor.author | Lee, Young Lim | - |
dc.contributor.author | Kim, Seong Su | - |
dc.contributor.author | Yang, Jae-Hyuk | - |
dc.contributor.author | Jang, Kiseok | - |
dc.contributor.author | Yang, Chul-Su. | - |
dc.contributor.author | Kim, Tae-Hwan | - |
dc.contributor.author | Kim, Yong-Hee | - |
dc.date.accessioned | 2021-06-22T09:10:48Z | - |
dc.date.available | 2021-06-22T09:10:48Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.issn | 1873-4995 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/1495 | - |
dc.description.abstract | Excessive tumor necrosis factor-α (TNF-α) is associated with the pathogenesis of rheumatoid arthritis (RA). Approximately 90% of patients with RA, who have inadequate response to methotrexate, follow anti-TNF-α therapy as the first-line immuno-treatment. However, ineffective long-term anti-TNF-α antibody cycling for 40% of non-responders to anti-TNF-α antibodies is costly and associated with various side effects, which needs alternative mechanism of action therapies. In the present study, a novel strategy to down-regulate TNF-α level was developed by using an alternative method of suppressing TNF-α converting enzyme (TACE), a transmembrane enzyme involved in cleaving and releasing bioactive soluble TNF-α. TACE suppression can be an effective remedy to block the production of soluble TNF-α, leading to an increased sensitivity to anti-TNF-α non-responders. A disease site-targeted RNA interference system was developed by forming non-viral complex between shRNA against TACE (shTACE) and bone resorption site-specific peptide carrier composed of aspartate repeating and arginine repeating sequences. The shTACE/peptide carrier complex alleviated arthritic symptoms in collagen induced arthritis (CIA) models by demonstrating enhanced anti-inflammatory and anti-osteoclastogenic effects. Similar results were obtained with human primary synovial cells and osteoclast precursor isolated from tissues and synovial fluids of RA patients. Taken together, the shTACE/targeting peptide complex provides a strong potential as an alternative anti-TNF-α therapeutic for RA treatment. © 2020 Elsevier B.V. | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | RNA interference-mediated suppression of TNF-α converting enzyme as an alternative anti-TNF-α therapy for rheumatoid arthritis | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.jconrel.2020.11.041 | - |
dc.identifier.scopusid | 2-s2.0-85097191904 | - |
dc.identifier.wosid | 000626459100097 | - |
dc.identifier.bibliographicCitation | Journal of Controlled Release, v.330, pp 1300 - 1312 | - |
dc.citation.title | Journal of Controlled Release | - |
dc.citation.volume | 330 | - |
dc.citation.startPage | 1300 | - |
dc.citation.endPage | 1312 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | Amino acids | - |
dc.subject.keywordPlus | Antibodies | - |
dc.subject.keywordPlus | Cell death | - |
dc.subject.keywordPlus | Enzymes | - |
dc.subject.keywordPlus | Patient treatment | - |
dc.subject.keywordPlus | Peptides | - |
dc.subject.keywordPlus | RNA | - |
dc.subject.keywordPlus | Anti-inflammatories | - |
dc.subject.keywordPlus | Collagen-induced arthritis | - |
dc.subject.keywordPlus | Converting enzyme | - |
dc.subject.keywordPlus | Mechanism of action | - |
dc.subject.keywordPlus | Osteoclast precursor | - |
dc.subject.keywordPlus | Rheumatoid arthritis | - |
dc.subject.keywordPlus | RNA interference | - |
dc.subject.keywordPlus | Tumor necrosis factor alpha | - |
dc.subject.keywordPlus | Diseases | - |
dc.subject.keywordAuthor | Gene therapy | - |
dc.subject.keywordAuthor | Human primary synovial cells and osteoclast precursor | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
dc.subject.keywordAuthor | TNF-α converting enzyme | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S016836592030691X?via%3Dihub | - |
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